Specific features of hemodynamics in individuals with different body mass: correlation with composition of the body and insulin resistance

Abstract

Objective of the work — to determine changes of hemodynamic parameters by integral rheography of the body technique in Kharkiv adult population with different body mass in correlation to its composition, specifics of adipose tissue accumulation topography, liquid areas, presence and degree of insulin resistance. Material and methods. 250 individuals (mean age 65.48±11.86 year) were examined. Patients with arterial hypertension, coronary artery disease and cardiac failure were excluded from the examination. The body mass index was calculated, waist and hip circumferences were measured in the examined patients; adipose, fat-free active body cell mass, total liquid contents and blood volume were determined by bioimpedance technique; systolic volume, cardiac ejection, systolic and heart indices, integral tonicity coefficient were revealed by integral rheography of the
body; systolic and diastolic arterial pressure were measured; HOMA insulin resistance index was determined. Results. It was proved that increasing body mass from normal to overweight and obesity class 1, 2, 3 reveals growing volume of total liquid at statistically valid values p<0.001; p<0.05; p<0.001 and p<0.001, respectively. It was determined that while body mass increases from normal to overweight mass; from obesity class 1 to obesity class 2; from obesity class 2 to obesity class 3, blood level also grows statistically valid (p<0.001; p<0.014 and p<0.001, respectively). Patients with overweight body mass, obesity class 1 and class 2 are characterized with absolute increase of systolic heart function according to the determined beat volume and cardiac output. In obesity class 3 relative systolic failure developed relatively to the body square. Statistically valid correlation between parameters of systolic function and body mass index, accumulation either adipose or fat-free mass in the body was found. It was determined that changes of systemic arterial tone in overweight subjects are mostly connected with contents in the body fat-free tissues. Evidence of correlation between insulin resistance and levels of systolic volume, cardiac ejection, coefficient of integral tonicity, systolic and diastolic arterial pressure has been confirmed by statistical difference at p<0.001 level of these parameters in the groups of patients with insulin resistance and normal tissue insulin sensitivity. Conclusions. Representatives of Ukrainian population with overweight body mass of different classes are proved to have correlation between parameters of cardiac systolic function and changes of body composition, liquid areas, degree of accumulated visceral adipose tissue. At insulin resistance evidence, these shifts are intensified.