Keywords
diabetes mellitus, pathogenesis, diabetic nephropathy, transforming growth factor-β1.
How to Cite
Tsymbal, T. (2013). Features of the pathogenesis and treatment of diabetic nephropathy (literature review and own data). Endokrynologia, 18(4), 63-70. Retrieved from https://endokrynologia.com.ua/index.php/journal/article/view/365
Abstract
The review presents modern views on the pathogenetic mechanisms of development of diabetic nephropathy in patients with type 1 diabetes mellitus. The phasing of interstitial fibrosis of kidneys and importance of transforming growth factor-β1 in the process were shown.
References
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99-102. (Semidotskaya M.D., Pererva L.A. Diabetic nephropathy: pathogenesis, clinics, prognosis // Int. Med. J. 2004,4,99-102).
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10. Chow F., Ozols E., Nicolic-Paterson D.J. et al Macrophages in mouses type 2 diabetic nephropathy: correlation with diabetic state and progressed renal injury // Kidney Int. 2004, 65, 116-128.
11. Kelly D.J., Chanty A., Gow R.M et al. Proteinkinase inhibition jsteoponin expression, macrophage recruitment and tubulointerstisial unjury in advanced
experemental diabetic nephropathy // J. Am. Soc. Nephrol. 2005, 16, 1654-1660.
12. Klimontov V.V., Bondar I.A., Nadeev A.P. Increased urinary excretion proinflammatory cytokines is associated with renal structural changes in type 1 diabetic patients // Diabetologia. 2007, 50, Suppl. 1, S467.
13. Sassy-Prigent C., Heudes D., Mandet C. Early glomerular macrophage recruitment in streptozotocininduced diabetic rats // Diabetes. 2000, 49, 466-475.
14. Mezzano S., Aros C., Droduett A. NF-kappaB activation and overexpression of regulated genes in human diabetic nephropathy // Nephrol. Dial. Trasplant. 2004, 19, 2505-2512.
15. Harther A., Veelken R., Wittman M. et al. Effects of diabetes and hypertention on macrophage infiltration and matrix expensiob in the rat kidney // BMC Nephrol. 2005, 6, 1-6.
Nutrition Examination Survey // Am. J. Kidney Dis. 2003, 41, 1-12.
2. National Kidney Foundation: K/DOQI clinical practice guidelines for chronic kidney disease: Evolution, classification and stratification // Am. J. Kidney Dis.
2007, 1, 1-39.
3. Смирнов А. В., Каюков И. Г., Есаян А. М. и др. Превентивный подход к современной нефрологии // Нефрология. 2004, 3, 7-14. (Smirnov A.V., Kayukov I.G.,
Esayan A.M. et al. Preventive approach to contemporary nephrology // Nephrology. 2001, N 3, 7-14).
4. Бондарь И. А., Климонтов В. В. Тубулоинтерсти- циальный фиброз при диабетической нефропатии: механизмы развития и подходы к лечению // Сахарный диабет. 2008, 2, 11-15. (Bondar I.A., Klimontov V.V. Tubulointerstitial fibrosis at diabetic nephropathy: mechanisms of development and approaches to treatment // Diabetes mellitus. 2008, N 2, 11-15).
5. Marcussen N. Atubular glomeruli in cisplatin-induced chronic interstitial nephropathy // APMIS.1990, 98, 1080-1097.
6. Marcussen N. Tubulointerstisial damage leads to atubular gromerul: significance and possible role in progres // Nephrol. Dial. Transplant. 2000, 1, 74-75.
7. Okon K. Tubulointerstisial changes in glomerulopathy. Prognostic significans // Pol. J. Pathol. 2003, 54, 3-13.
8. Семидоцкая М.Д., Перерва Л.А. Диабетическая нефропатия: патогенез, клиника, прогноз // Международный медицинский журнал. 2004, 4,
99-102. (Semidotskaya M.D., Pererva L.A. Diabetic nephropathy: pathogenesis, clinics, prognosis // Int. Med. J. 2004,4,99-102).
9. Segerer S., Nelson P., Schlondorff D. Receptors and renal disease: from basic pathophysiologic and therapetic studies // J. Am. Nephrol. 2000, 11, 152-176.
10. Chow F., Ozols E., Nicolic-Paterson D.J. et al Macrophages in mouses type 2 diabetic nephropathy: correlation with diabetic state and progressed renal injury // Kidney Int. 2004, 65, 116-128.
11. Kelly D.J., Chanty A., Gow R.M et al. Proteinkinase inhibition jsteoponin expression, macrophage recruitment and tubulointerstisial unjury in advanced
experemental diabetic nephropathy // J. Am. Soc. Nephrol. 2005, 16, 1654-1660.
12. Klimontov V.V., Bondar I.A., Nadeev A.P. Increased urinary excretion proinflammatory cytokines is associated with renal structural changes in type 1 diabetic patients // Diabetologia. 2007, 50, Suppl. 1, S467.
13. Sassy-Prigent C., Heudes D., Mandet C. Early glomerular macrophage recruitment in streptozotocininduced diabetic rats // Diabetes. 2000, 49, 466-475.
14. Mezzano S., Aros C., Droduett A. NF-kappaB activation and overexpression of regulated genes in human diabetic nephropathy // Nephrol. Dial. Trasplant. 2004, 19, 2505-2512.
15. Harther A., Veelken R., Wittman M. et al. Effects of diabetes and hypertention on macrophage infiltration and matrix expensiob in the rat kidney // BMC Nephrol. 2005, 6, 1-6.
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