The cytological features оf thyrocyte population of radioiodine-resistant metastases of papillary thyroid cancer in their pre-operational prediction

Abstract

Aim is cytomorphological and imunocytochemical studies of thyrocyte populations in punctuates of radioiodine resistant metastases compared to radioiodine sensitive those and primary papillary thyroid cancer, and identification of thyrocyte phenotypic features to create the methods for preoperational prognosis of radioiodineresistant papillary thyroid metastases. Material and methods. Cytomorphological and imunocytochemical studies using monoclonal antibodies against thyroid peroxidase, thyroglobulin, cytokeratinum 7, 8, and antigen Ki-67 were performed on the material of the thin-puncture biopsies of 45 papillary carcinomas and their metastases detected in the postoperative period (30 — radioiodine resistant, 15 — radioiodine sensitive). Results. It was shown that radioiodine resistant metastases of papillary thyroid carcinoma demonstrated phenotypic heterogeneity of thyrocyte population unlike radioiodine sensitive metastases and appearance of cellular types and structures that are absent in primary papillary thyroid cancer and radioiodine sensitive metastases. The cytological sign of phenotypic heterogeneity of thyrocyte population with low expression of thyroid peroxidase can be cytological preoperative factors predicting radioiodine resistant metastases of papillary thyroid cancer arising in the postoperative period and can be used in practice.