Diabetes and atherosclerosis. Cellular mechanisms of the pathogenesis. Literature review
Vol. 22 No. 2 (2017), REVIEWS
Vol. 22 No. 2 (2017)

Diabetes and atherosclerosis. Cellular mechanisms of the pathogenesis. Literature review

REVIEWS
Published June 29, 2017
Л.К. Соколова
SI «V.P. Komissarenko Institute of Endocrinology and Metabolism of NAMS of Ukraine»
V.M. Pushkarev
SI «V.P. Komissarenko Institute of Endocrinology and Metabolism of NAMS of Ukraine»
V.V. Pushkarev
SI «V.P. Komissarenko Institute of Endocrinology and Metabolism of NAMS of Ukraine»
N.D. Tronko
SI «V.P. Komissarenko Institute of Endocrinology and Metabolism of NAMS of Ukraine»
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Keywords

atherosclerosis, diabetes, endothelium, vascular cells, NF-κB

How to Cite

Соколова, Л., Pushkarev, V., Pushkarev, V., & Tronko, N. (2017). Diabetes and atherosclerosis. Cellular mechanisms of the pathogenesis. Literature review. Endokrynologia, 22(2), 127-138. Retrieved from https://endokrynologia.com.ua/index.php/journal/article/view/69
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Abstract

The review of the literature analyzes the cellular mechanisms of the pathogenesis of the complication of diabetes mellitus — the accelerated development of atherosclerosis. The mechanisms of metabolic impairment and the genesis of endothelial dysfunction in diabetes mellitus have been analyzed; the role of intercellular junctions of vascular endothelial cells to support vascular integrity and permeability barrier in norm and pathology has been shown. Data on involvement in the pathogenesis of atherosclerosis on the background of diabetes mellitus of vascular smooth muscle cells, macrophages, platelets and erythrocytes are summarized. The role of the nuclear factor NF-κB — regulator of inflammatory reactions in endothelial cells, vascular smooth muscle cells and macrophages is shown.

Pdf (Українська)

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