Metabolic syndrome – dietary recommendations and nutraceutical correction
pdf (Українська)

Keywords

metabolic syndrome, diet, nutraceuticals, Solgar Company

How to Cite

NyankovskaО., Nyankovskyy, S., Yatsula, M., & Horodylovska, M. (2021). Metabolic syndrome – dietary recommendations and nutraceutical correction. Endokrynologia, 26(4), 396-408. https://doi.org/10.31793/1680-1466.2021.26-4.396

Abstract

Metabolic syndrome (MS) is defined as the coexistence of risk factors of metabolic origin (insulin resistance, hyperinsulinemia, impaired glucose tolerance, type 2 diabetes mellitus, visceral obesity, atherogenic dyslipidaemia and/or, high blood pressure) that elevate risk for cardiovascular disease. According to the 2019 Health Index survey, every second Ukrainian adult (53.7%) is overweight. In addition to genetic predisposition, there are important environmental factors that can influence the pathogenesis of MS. Certain lifestyle changes can have a positive effect on the course of MS. The aim of the article is to consider the current data on the influence of nutrition and different nutraceuticals on the metabolic syndrome. Epidemiological evidence suggests that a diet high in fruits, vegetables, fish, and whole grains may improve all of the risk factors associated with MS. The Mediterranean diet is characterized by an adequately balanced combination of fruits, vegetables, fish, cereals and polyunsaturated fats, with reduced consumption of meat and dairy products and moderate consumption of alcohol, especially red wine. Consumption of products containing antioxidant compounds with anti-inflammatory action has been shown to reduce the incidence of MS and improve the dynamics of the components which determine this pathological condition. Whole grains, fruits, vegetables and legumes provide the optimal combination of bioactive components, vitamins, minerals, phytochemicals and antioxidants. The cardioprotective effects of the Mediterranean diet are well known and widely documented in epidemiological studies and clinical trials. The use of nutraceuticals for the treatment of disease,
for example MS, is the alternative form of modern medicine. Solgar Company has variety of biologically active supplements, including many nutraceuticals for MS, in particular curcumin, resveratrol, omega‑3 fatty acids, lipotropic factors, chromium picolinate and others.

https://doi.org/10.31793/1680-1466.2021.26-4.396
pdf (Українська)

References

Stanley S Wang. Metabolic syndrome. Available from: https://emedicine.medscape.com/article/165124-overview [Accessed 15th August 2021].

Kassi E, Pervanidou P, Kaltsas G, Chrousos G. Metabolic syndrome: definitions and controversies. BMC Med. 2011 May 5;9:48. doi: 10.1186/1741-7015-9-48.

Rabe K, Lehrke M, Parhofer KG, Broedl UC. Adipokines and insulin resistance. Mol Med. 2008 Nov-Dec;14(11-12):741-51. doi: 10.2119/2008-00058.Rabe.

Mansego ML, Redon J, Martinez-Hervas S, Real JT, Martinez F, Blesa S, et al. Different impacts of cardiovascular risk factors on oxidative stress. Int J Mol Sci. 2011;12(9):6146-63. doi: 10.3390/ ijms12096146.

Stern MP, Williams K, González-Villalpando C, Hunt KJ, Haffner SM. Does the metabolic syndrome improve identification of individuals at risk of type 2 diabetes and/or cardiovascular disease? Diabetes Care. 2004 Nov;27(11):2676-81. doi: 10.2337/diacare.27.11.2676.

Індекс Здоров’я. Україна‑2019: Результати загальнонаціонального дослідження (Health Index. Ukraine‑2019: Results national research). Kyiv: Health Index Ukraine; 2020. Available from: http://health-index.com.ua/HI_Report_2019_Preview.pdf. [Accessed 15th August 2021].

Kaur J. A comprehensive review on metabolic syndrome. Cardiol Res Pract. 2014;2014:943162. doi: 10.1155/2014/943162.

Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev. 2009;2(5):270-8. doi:10.4161/oxim.2.5.9498.

Alissa EM, Ferns GA. Functional foods and nutraceuticals in the primary prevention of cardiovascular diseases. J Nutr Metab. 2012;2012:569486. doi: 10.1155/2012/569486.

Ooi EM, Watts GF, Ng TW, Barrett PH. Effect of dietary fatty acids on human lipoprotein metabolism: a comprehensive update. Nutrients. 2015 Jun 2;7(6):4416-25. doi: 10.3390/nu7064416.

Abete I, Goyenechea E, Zulet MA, Martínez JA. Obesity and metabolic syndrome: potential benefit from specific nutritional components. Nutr Metab Cardiovasc Dis. 2011 Sep;21 Suppl 2: B1-15. doi: 10.1016/j.numecd.2011.05.001.

Giglio RV, Patti AM, Nikolic D, Li Volti G, Al-Rasadi K, Katsiki N, et al. The effect of bergamot on dyslipidemia. Phytomedicine. 2016 Oct 15;23(11):1175-81. doi: 10.1016/j.phymed.2015.12.005.

Martínez-González MÁ, Martín-Calvo N. The major European dietary patterns and metabolic syndrome. Rev Endocr Metab Disord. 2013 Sep;14(3):265-71. doi: 10.1007/s11154-013-9264-6.

Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Saturated fat, carbohydrate, and cardiovascular disease. Am J Clin Nutr. 2010;91(3):502-9. doi:10.3945/ajcn.2008.26285.

Schwingshackl L, Hoffmann G. Monounsaturated fatty acids, olive oil and health status: a systematic review and meta-analysis of cohort studies. Lipids Health Dis. 2014 Oct 1;13:154. doi: 10.1186/1476-511X‑13-154.

Xavier Medina F. Mediterranean diet, culture and heritage: challenges for a new conception. Public Health Nutr. 2009 Sep;12(9A):1618-20. doi: 10.1017/S1368980009990450.

Eat like the mediterraneans and lower risk of metabolic syndrome and cognitive impairment. Available from: https://drmarkcrapo.typepad.com/dr_marks_web_blog/2009/03/eat-like-the-mediterraneans-and-lower-risk-of-metabolic-syndrome-and-cognitive-impairment-.html [Accessed 09th March 2009].

Trichopoulou A, Costacou T, Bamia C, Trichopoulos D. Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med. 2003 Jun 26;348(26):2599-608. doi: 10.1056/NEJMoa025039.

Esposito K, Chiodini P, Colao A, Lenzi A, Giugliano D. Metabolic syndrome and risk of cancer: a systematic review and meta-analysis. Diabetes Care. 2012 Nov;35(11):2402-11. doi: 10.2337/dc12-0336.

Askarpour M, Hadi A, Miraghajani M, Symonds ME, Sheikhi A, Ghaedi E. Beneficial effects of l-carnitine supplementation for weight management in overweight and obese adults: An updated systematic review and dose-response meta-analysis of randomized controlled trials. Pharmacol Res. 2020 Jan;151:104554. doi: 10.1016/j.phrs.2019.104554.

Chacko SM, Thambi PT, Kuttan R, Nishigaki I. Beneficial effects of green tea: a literature review. Chin Med. 2010;5:13. Published 2010 Apr 6. doi:10.1186/1749-8546-5-13.

Basu A, Sanchez K, Leyva MJ, Wu M, Betts NM, Aston CE, et al. Green tea supplementation affects body weight, lipids, and lipid peroxidation in obese subjects with metabolic syndrome. J Am Coll Nutr. 2010 Feb;29(1):31-40. doi: 10.1080/07315724.2010.10719814.

Mousavi A, Vafa M, Neyestani T, Khamseh M, Hoseini F. The effects of green tea consumption on metabolic and anthropometric indices in patients with Type 2 diabetes. J Res Med Sci. 2013;18(12):1080-6.

Simopoulos AP. The importance of the ratio of omega‑6/omega‑3 essential fatty acids. Biomed Pharmacother. 2002 Oct;56(8):365-79. doi: 10.1016/s0753-3322(02)00253-6.

Poudyal H, Panchal SK, Diwan V, Brown L. Omega‑3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action. Prog Lipid Res. 2011 Oct;50(4):372-87. doi: 10.1016/j. plipres.2011.06.003.

Du S, Jin J, Fang W, Su Q. Does fish oil have an anti-obesity effect in overweight/obese adults? A meta-analysis of randomized controlled trials. PLoS One. 2015 Nov 16;10(11): e0142652. doi: 10.1371/journal.pone.0142652.

Jurgoński A, Juśkiewicz J, Zduńczyk Z. Ingestion of black chokeberry fruit extract leads to intestinal and systemic changes in a rat model of prediabetes and hyperlipidemia. Plant Foods Hum Nutr. 2008 Dec;63(4):176-82. doi: 10.1007/s11130-008-0087-7.

Christenson J, Whitby SJ, Mellor D, Thomas J, McKune A, Roach PD, Naumovski N. The effects of resveratrol supplementation in overweight and obese humans: a systematic review of randomized trials. Metab Syndr Relat Disord. 2016 Sep;14(7):323-33. doi: 10.1089/met.2016.0035.

Dinca M, Serban MC, Sahebkar A, Mikhailidis DP, Toth PP, Martin SS, et al. Does vitamin D supplementation alter plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 2016 May;107:360-71. doi: 10.1016/j.phrs.2016.03.035.

Nimitphong H, Samittarucksa R, Saetung S, Bhirommuang N, Chailurkit LO, Ongphiphadhanakul B. The effect of vitamin D supplementation on metabolic phenotypes in Thais with prediabetes. J Med Assoc Thai. 2015 Dec;98(12):1169-78.

Di Pierro F, Bressan A, Ranaldi D, Rapacioli G, Giacomelli L, Bertuccioli A. Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome. Preliminary study. Eur Rev Med Pharmacol Sci. 2015 Nov;19(21):4195-202.

Langley P. Why a pomegranate? BMJ. 2000;321(7269):1153-4. doi:10.1136/bmj.321.7269.11.

Ben Nasr C, Ayed N, Metche M. Quantitative determination of the polyphenolic content of pomegranate peel. Z Lebensm Unters Forsch. 1996 Oct;203(4):374-8. doi: 10.1007/BF01231077.

Stowe CB. The effects of pomegranate juice consumption on blood pressure and cardiovascular health. Complement Ther Clin Pract. 2011 May;17(2):113-5. doi: 10.1016/j.ctcp.2010.09.004.

Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis. 2001 Sep;158(1):195-8. doi: 10.1016/s0021-9150(01)00412-9.

Galley HF, Thornton J, Howdle PD, Walker BE, Webster NR. Combination oral antioxidant supplementation reduces blood pressure. Clin Sci (Lond). 1997 Apr;92(4):361-5. doi: 10.1042/cs0920361.

Bogdanski P, Suliburska J, Szulinska M, Stepien M, Pupek-Musialik D, Jablecka A. Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients. Nutr Res. 2012 Jun;32(6):421-7. doi: 10.1016/j.nutres.2012.05.007.

Mikaili P, Maadirad S, Moloudizargari M, Aghajanshakeri S, Sarahroodi S. Therapeutic uses and pharmacological properties of garlic, shallot, and their biologically active compounds. Iran J Basic Med Sci. 2013;16(10):1031-48.

Ried K, Fakler P. Potential of garlic (Allium sativum) in lowering high blood pressure: mechanisms of action and clinical relevance. Integr Blood Press Control. 2014;7:71-82. Published 2014 Dec 9. doi:10.2147/IBPC.S51434.

Gómez-Arbeláez D, Lahera V, Oubiña P, Valero-Muñoz M, de Las Heras N, Rodríguez Y, et al. Aged garlic extract improves adiponectin levels in subjects with metabolic syndrome: a double-blind, placebo-controlled, randomized, crossover study. Mediators Inflamm. 2013;2013:285795. doi: 10.1155/2013/285795.

Houston M. The role of nutrition and nutraceutical supplements in the treatment of hypertension. World J Cardiol. 2014;6(2):38-66. doi:10.4330/wjc.v6.i2.38.

Kleemann R, Verschuren L, Morrison M, Zadelaar S, van Erk MJ, Wielinga PY, et al. Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models. Atherosclerosis. 2011 Sep;218(1):44-52. doi: 10.1016/j. atherosclerosis.2011.04.023.

Serban MC, Sahebkar A, Zanchetti A, Mikhailidis DP, Howard G, Antal D, et al. Lipid and Blood Pressure Meta‐analysis Collaboration (LBPMC) Group. Effects of quercetin on blood pressure: a systematic review and meta-analysis of randomized controlled trials. J Am Heart Assoc. 2016 Jul 12;5(7): e002713. doi: 10.1161/JAHA.115.002713.

Elliott P, Kesteloot H, Appel LJ, Dyer AR, Ueshima H, Chan Q, et al. Dietary phosphorus and blood pressure: international study of macro- and micro-nutrients and blood pressure. Hypertension. 2008 Mar;51(3):669-75. doi: 10.1161/HYPERTENSIONAHA. 107.103747.

Askarpour M, Hadi A, Symonds ME, Miraghajani M, Omid Sadeghi, Sheikhi A, et al. Efficacy of l-carnitine supplementation for management of blood lipids: A systematic review and dose-response meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis. 2019 Nov;29(11):1151-67. doi: 10.1016/j.numecd. 2019.07.012.

Rebello CJ, Burton J, Heiman M, Greenway FL. Gastrointestinal microbiome modulator improves glucose tolerance in overweight and obese subjects: A randomized controlled pilot trial. J Diabetes Complications. 2015 Nov-Dec;29(8):1272-6. doi: 10.1016/j.jdiacomp. 2015.08.023.

Broncel M, Koziróg-Kołacińska M, Andryskowski G, Duchnowicz P, Koter-Michalak M, Owczarczyk A, et al. Wpływ antocyjanin z aronii czarnoowocowej na ciśnienie tetnicze oraz stezenie endoteliny‑1 i lipidów u pacjentów z zespołem metabolicznym [Effect of anthocyanins from Aronia melanocarpa on blood pressure, concentration of endothelin‑1 and lipids in patients with metabolic syndrome]. Pol Merkur Lekarski. 2007 Aug;23(134):116-9. Polish.

Sicińska P, Pytel E, Maćczak A, Koter-Michalak M. Zastosowanie różnych suplementów diety w zespole metabolicznym [The use of various diet supplements in metabolic syndrome]. Postepy Hig Med Dosw (Online). 2015 Jan 9;69:25-33. Polish. doi: 10.5604/17322693.1135416.

Kojima Y, Kimura T, Nakagawa K, et al. Effects of mulberry leaf extract rich in 1-deoxynojirimycin on blood lipid profiles in humans. J Clin Biochem Nutr. 2010;47(2):155-61. doi:10.3164/jcbn.10-53.

Berneis K, Rizzo M, Berthold HK, Spinas GA, Krone W, Gouni-Berthold I. Ezetimibe alone or in combination with simvastatin increases small dense low-density lipoproteins in healthy men: a randomized trial. Eur Heart J. 2010 Jul;31(13):1633-9. doi: 10.1093/eurheartj/ehq181.

Mikhailidis DP, Elisaf M, Rizzo M, Berneis K, Griffin B, Zambon A, et al. «European panel on low density lipoprotein (LDL) subclasses»: a statement on the pathophysiology, atherogenicity and clinical significance of LDL subclasses: executive summary. Curr Vasc Pharmacol. 2011 Sep;9(5):531-2. doi: 10.2174/157016111796642698.

Vincent JB. Chromium: celebrating 50 years as an essential element? Dalton Trans. 2010 Apr 28;39(16):3787-94. doi: 10.1039/b920480f.

Guallar E, Jiménez FJ, van ‘t Veer P, Bode P, Riemersma RA, Gómez-Aracena J, et al. Low toenail chromium concentration and increased risk of nonfatal myocardial infarction. Am J Epidemiol. 2005 Jul 15;162(2):157-64. doi: 10.1093/aje/kwi180.

Anderson RA, Polansky MM, Bryden NA, Roginski EE, Mertz W, Glinsmann W. Chromium supplementation of human subjects: effects on glucose, insulin, and lipid variables. Metabolism. 1983 Sep;32(9):894-9. doi: 10.1016/0026-0495(83)90203-2.

Anderson RA, Polansky MM, Bryden NA, Canary JJ. Supplemental-chromium effects on glucose, insulin, glucagon, and urinary chromium losses in subjects consuming controlled low-chromium diets. Am J Clin Nutr. 1991 Nov;54(5):909-16. doi: 10.1093/ ajcn/54.5.909.

Offenbacher EG, Pi-Sunyer FX. Beneficial effect of chromium-rich yeast on glucose tolerance and blood lipids in elderly subjects. Diabetes. 1980 Nov;29(11):919-25. doi: 10.2337/diab.29.11.919.

Abraham AS, Brooks BA, Eylath U. The effects of chromium supplementation on serum glucose and lipids in patients with and without non-insulin-dependent diabetes. Metabolism. 1992 Jul;41(7):768-71. doi: 10.1016/0026-0495(92)90318-5.

Zeisel SH, Blusztajn JK. Choline and human nutrition. Annu Rev Nutr. 1994;14:269-96. doi: 10.1146/annurev.nu.14.070194.001413.

Buchman AL, Dubin MD, Moukarzel AA, Jenden DJ, Roch M, Rice KM, et al. Choline deficiency: a cause of hepatic steatosis during parenteral nutrition that can be reversed with intravenous choline supplementation. Hepatology. 1995 Nov;22(5):1399-403.

Croze ML, Soulage CO. Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie. 2013 Oct;95(10):1811-27. doi: 10.1016/j.biochi.2013.05.011.

Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Saturated fatty acids and risk of coronary heart disease: modulation by replacement nutrients. Curr Atheroscler Rep. 2010 Nov;12(6):384-90. doi: 10.1007/s11883-010-0131-6.

Ballantyne CM, Bays HE, Kastelein JJ, Stein E, Isaacsohn JL, Braeckman RA, et al. Efficacy and safety of eicosapentaenoic acid ethyl ester (AMR101) therapy in statin-treated patients with persistent high triglycerides (from the ANCHOR study). Am J Cardiol. 2012 Oct 1;110(7):984-92. doi: 10.1016/j.amjcard.2012.05.031.

Pryor WA. Vitamin E and heart disease: basic science to clinical intervention trials. Free Radic Biol Med. 2000 Jan 1;28(1):141-64. doi: 10.1016/s0891-5849(99)00224-5.

Goel H, Dunbar RL. Niacin Alternatives for Dyslipidemia: Fool’s Gold or Gold Mine? Part II: Novel Niacin Mimetics. Curr Atheroscler Rep. 2016;18(4):17. doi: 10.1007/s11883-016-0570-9.

Morgan JM, Capuzzi DM, Guyton JR. A new extended-release niacin (Niaspan): efficacy, tolerability, and safety in hypercholesterolemic patients. Am J Cardiol. 1998 Dec 17;82(12A):29U‑34U; discussion 39U‑41U. doi: 10.1016/s0002-9149(98)00732-2.

Liu ZM, Ho SC, Chen YM, Ho S, To K, Tomlinson B, et al. Whole soy, but not purified daidzein, had a favorable effect on improvement of cardiovascular risks: a 6-month randomized, double-blind, and placebo-controlled trial in equol-producing postmenopausal women. Mol Nutr Food Res. 2014 Apr;58(4):709-17. doi: 10.1002/mnfr.201300499.

Partida-Hernández G, Arreola F, Fenton B, Cabeza M, Román-Ramos R, Revilla-Monsalve MC. Effect of zinc replacement on lipids and lipoproteins in type 2-diabetic patients. Biomed Pharmacother. 2006 May;60(4):161-8. doi: 10.1016/j.biopha.2006.02.004.

Guerrero-Romero F, Rodríguez-Morán M. Hypomagnesemia, oxidative stress, inflammation, and metabolic syndrome. Diabetes Metab Res Rev. 2006 Nov-Dec;22(6):471-6. doi: 10.1002/dmrr.644.

Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev. 2010;4(8):118-26. doi:10.4103/0973-7847.70902

Romieu I, Garcia-Esteban R, Sunyer J, Rios C, Alcaraz-Zubeldia M, Velasco SR, et al. The effect of supplementation with omega‑3 polyunsaturated fatty acids on markers of oxidative stress in elderly exposed to PM(2.5). Environ Health Perspect. 2008 Sep;116(9):1237-42. doi: 10.1289/ehp.10578.

Rahman K. Studies on free radicals, antioxidants, and co-factors. Clin Interv Aging. 2007;2(2):219-36.

Naziroğlu M, Butterworth PJ. Protective effects of moderate exercise with dietary vitamin C and E on blood antioxidative defense mechanism in rats with streptozotocin-induced diabetes. Can J Appl Physiol. 2005 Apr;30(2):172-85. doi: 10.1139/h05-113.

Frishman WH. Nutriceuticals as treatments for cardiovascular disease. Heart Dis. 1999 May-Jun;1(2):51.

Mikirova NA, Ichim TE, Riordan NH. Anti-angiogenic effect of high doses of ascorbic acid. J Transl Med. 2008 Sep 12;6:50. doi:10.1186/1479-5876-6-50.

Vasan RS. Biomarkers of cardiovascular disease: molecular basis and practical considerations. Circulation. 2006 May 16;113(19):2335-62. doi: 10.1161/CIRCULATIONAHA.104.482570.

Khaw KT, Bingham S, Welch A, Luben R, Wareham N, Oakes S, et al. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition. Lancet. 2001 Mar 3;357(9257):657-63. doi: 10.1016/s0140-6736(00)04128-3.

Serban MC, Sahebkar A, Mikhailidis DP, Toth PP, Jones SR, Muntner P, et al. Impact of L-carnitine on plasma lipoprotein(a) concentrations: A systematic review and meta-analysis of randomized controlled trials. Sci Rep. 2016 Jan 12;6:19188. doi: 10.1038/srep19188.

Serban C, Sahebkar A, Ursoniu S, Andrica F, Banach M. Effect of sour tea (Hibiscus sabdariffa L.) on arterial hypertension: a systematic review and meta-analysis of randomized controlled trials. J Hypertens. 2015 Jun;33(6):1119-27. doi: 10.1097/ HJH.0000000000000585.

Ursoniu S, Sahebkar A, Andrica F, Serban C, Banach M; Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group. Effects of flaxseed supplements on blood pressure: A systematic review and meta-analysis of controlled clinical trial. Clin Nutr. 2016 Jun;35(3):615-25. doi: 10.1016/j.clnu.2015.05.012.

Ursoniu S, Sahebkar A, Serban MC, Banach M. Lipid profile and glucose changes after supplementation with astaxanthin: a systematic review and meta-analysis of randomized controlled trials. Arch Med Sci. 2015 Apr 25;11(2):253-66. doi: 10.5114/aoms.2015.50960.

Downloads

Download data is not yet available.