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Abstract
Aim — to study the early markers of atherosclerosis (intimamedia thickness, presence of atherosclerotic plaques in the carotid arteries, and ankle-brachial index) and cardiovascular risk in women with hypertensive disease and hypothyroidism. Methods. 134 women (mean age 56.8 ± 0.5 years) with hypertensive disease were examined for studying the relationship between subclinical hypothyroidism (SH) and markers of atherosclerosis and cardiovascular risk. 4 groups of patients were formed depending on thyroid function: with newly diagnosed SH, with compensated hypothyroidism against the background of levothyroxine taking, with newly diagnosed manifested hypothyroidism, and without thyroid dysfunction. Results. Significant higher frequency of the intima-media thickness, and prevalence of atherosclerotic plaques in the carotid arteries of hypothyroid women comparing to euthyroid patients — 66.7% vs 45.7% and 45.5% vs 31.4%; and low indicators of ankle-brachial index — 1.07±0.02 vs 1.16±0.02 were established respectively. The high and very high risk was found in 36.4% women with hypertensive disease and manifested hypothyroidism against the background of SH by SCORE scale while the percent of detection is increased by 75.7% with accounting ultrasound data of the carotid arteries and ankle-brachial index. Conclusion. Adverse effect of SH on early markers of atherosclerosis and cardiovascular risk in women with hypertensive disease was confirmed. Hypothyroidism was associated with increased level of total cholesterol, LDL-cholesterol, intima-media thickness, and decreased ankle-brachial index. Women with arterial hypertension and SH against the background of levothyroxin treatment have the better lipids profile and lower cardiovascular risk comparing to patients with arterial hypertension and SH without levothyroxine replacement therapy.
References
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