Abstract
The information about the hormones of adipose tissue – adipokines, and their role in the pathogenesis of endocrine, particularly type 2 diabetes mellitus, as well as other diseases is presented. The peculiarities of their biosynthesis, mechanisms of action and biological activity are analyzed.
References
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relation to the metabolic syndrome // Horm. Metab. Res. 2002, 34, 616-621.
3. Gaillard S., Gaillard R. // Obesity & Metabolism. 2007, 3, 191-205.
4. Rosenbaum M., Leibel R.L. Clinical review 107. Role of gonadal steroids in the sexual dis-morphizm si body composition and circulating concentrations of leptin // J. Clin. Endocrinol. Metab. 1999, 84, 1784-1789.
5. Trayhurn P., Wood I.S. // Brit. J. Nutr. 2004, 92, 347–355.
6. Sierra-Honigmann M.R., Nath A.K., Murakami C. et al. Biological action of leptin as an angiogenic factor // Science. 1998, 281, 1683-1686.
7. Hassink S.G., Sheslow D.V., de Lancey E. et al. Serum leptin in children with obesity: relationship to gender and development // Pediatrics. 1996, 98, 201-203.
8. Lord G.M., Matarese G., Howard J.K. et al. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression // Nature.
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20, N 8, 1206-1208.
14. Kieffer T.J., Habener J.F.. The adipoinsular axis: effects of leptin on pancreatic beta-cells // Am. J. Physiol. 2000, 278, 1-14.
15. Maffei M., Hallas J., Ravussin E. et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects // Nat. Med. 1995, 1, 1155-1161.
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