Abstract
Duplex transcranial scanning of intracranial segments of major arteries of the circle of Willis (middle and back), and V4 segment of spine cerebral arteries was performed in patients with hypothyroidism, associated with arterial hypertension and without it. The value of systolic blood velocity and vascular reactivity was
analyzed on the basis of functional tests for studying myogenic and metabolic mechanisms of blood vessels regulation. A decrease in systolic blood flow velocity in the middle cerebral artery was found on one side of the brain and both sides of the vertebral arteries. Hemodynamic disorders were accompanied by changes in vascular reactivity in 50% of patients, as evidenced by the appearance of negative (in 41.67%) and paradoxical (in 8.33%) reactions at metabolic dilatory test. The observed changes were more common in patients with hypothyroidism, combined with arterial hypertension.
References
2. Верещагин Н.В., Моргунов В.А., Гулевская Т.С. Патология головного мозга при атеросклерозе и артериальной гипертензии. М.: Медицина. 1997, 8-61 .
3. Ермолаева А.И. Цереброваскулярные расстройства при гипотиреозе // Информ. издат. центр. 2008, 208. 11 ОС.
4. Hatsukami T.S., Ferguson M.S., Beach R.W. Carotid plaque morphology and its clinical events // Stroke. 1997, 28, 95-100.
5. Физлова И.Х. Гуранова Н.Н., Гурьянова Л.Н. и др. Ре- моделирование сосудистой стенки у больных с артериальной гипертензией // Матер. Рос. нац. конгресса кардиологов. М., 2010, 335-336.
6. Кунцевич Г.И. Ультразвуковые методы исследования ветвей дуги аорты. Минск: «Аверсэв». 2006, 208 с.
7. Баранова Г.А. Особенности хронической недостаточности мозгового кровообращения при гипотиреозе // Автореф. дис. канд. мед. наук. Саратов. 2011, 21 c.
8. Vela S. Эндокринная патология и сердечно-сосудистая система // Новости медицины и фармации. 2011, № 389, 14-34.
9. Котов С.В., Карпенко В.Г. Гипотиреоидная энцефалопатия // Вестник практ. неврол. 2003, №7, 65-69.
10. Jorde R., Joakiimsen O., Stensland E. Lack of significant association between intima-media thickness in the cаrotid artery and serum TSH level. The Troms Study // Thyroid. 2008, 18, N1, 21-25.
11. Tedgui A., Bardy N. Mechanical factors of the blood vessel // In: Intima-Media Thickness and Atherosclerosis. Predicting the Risk? ed). Ed. P.-J. Touboul. London, New York: The Parthenon Publishing Group, 1997. 69-74.
12. Korsgaard N., Aalkjaer C. Histology of subcutaneous small arteries from patients with essential hypertension // Hypertension. 1987, Suppl. 9, 155-159.
13. Clansen P., Mersebach H., Nelsen B. // Hypothyroidism is associated with signs of endothelial dysfunction despite 1-year replacement therapy with levothyroxine // Clin. Endocrinol. 2009, 70, N6, 932-937.
14. Manowitz N.R., Mayor G., Ridgway E.C. The Colorado thyroid disease prevalence study // Arch. Intern. Med. 2000, 160, 526-524.
15. Лелюк В.Г., Лелюк С.Э. Ультразвуковая ангиология. М.: Реальное время. 2003, 324 с.