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Abstract
At the present stage, the problem of the association of common rheumatic diseases, such as rheumatoid arthritis, osteoarthrosis and osteoporosis with diabetes mellitus, is relevant. To date, there is no single view on the role of biochemical and immunological factors that cause joint damage in conditions of comorbidity. The aim of thestudy was to evaluate the biochemical rheumatological parameters in patients with type 1 and type 2 diabetes with diabetes
associated osteoarthritis. Material and methods. The study involved 105 patients who were divided into groups by type of diabetes, the presence and severity of diabetic arthropathy. Patients were diagnosed with arthropathy using ultrasound of the joints, rheumatic tests were determined by immunoturbodimetric method. Results. In the group of patients with type 1 diabetes, arthropathy was found in 64.4% of patients, in the group of patients with type 2 diabetes — in 80.0% (t=1.8; p=0.07). Patients with arthropathy revealed a direct correlation between the stages of arthropathy and the factors «antistreptolysin» (r=0.33; p<0.01), «rheumatoid factor» (r=0.26; p<0.05) and «C-reactive protein» (r=0.43; p<0.001). An increase in the average level of uric acid with an increase in the
stage of arthropathy was established both in the group of patients with type 1 diabetes (F=4.4; p=0.009) and in the group with type 2 diabetes (F=17.9; p<0.001). Conclusions. Based on the data obtained, it is recommended to use the level of uric acid in the blood, rheumatoid factor and С-reactive protein as the most sensitive diagnostic criteria in patients with diabetes associated osteoarthritis.
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