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Abstract
The results of a clinical study of endothelial damage in patients with type 1 and type 2 diabetes mellitus (DM) are presented in the article. Aim — is to determine the nature and changes in the endothelial desquamation due to normalization of glycemia and the correction of concomitant pathology in patients with type 1 and 2 diabetes. Material and methods. 50 patients with type 1 and type 2 DM were involved in the study. Endothelial desquamation intensity was determined by modified Hladovec J. method. Results. Initially, the level of was 2530±694 cells/ml endotheliocytemia in patients with diabetes. Prescribed hypoglycemic therapy was associated with a clinically significant improvement of glycemic control — the average HbA1c level decreased from 8.42±0.2% to
7.36±0.3% (p<0.001). In three months from the beginning of the study, the level of circulating endothelial cells was established to be 32.57% lover with an average mean of 1706±58.9 cells/ml (p<0.001). The statistically significant difference in the level of endothelial desquamation between patients with type 1 and type 2 DM was not detected at all stages of the study.
References
2. Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart disease and stroke statistics — 2016 update. A report from the American Heart Association. Circulation. 2016; 133(4): e38-360.
3. Gozhenko AI, Kuznetsova HS, Kuznetsov SH, Kuznetsova KS, Byts TM. The number of circulating endotheliocytes in the blood plasma of the patients with diabetes mellitus increases Pharmacologyonline, 2017; 3: 23-6.
4. Omidian М, Abshirini М, Djalali М, Omidian Р, Zarei М, Hasani Н, Djalali М. The effects of vitamin D supplementation on serum levels and gene expression of some inflammatory and endothelial biomarkers in patients with type‑2 diabetes mellitus: a study protocol for a randomized double-blind controlled trial. IOSR J Pharmacy (IOSRPHR), 2019; 9(1): 06-11.
5. Kuznetsova HS, Kuznetsova KS, Byts TM, Bobryk LM, Kuznetsova OM, Gozhenko AI. Mechanisms of regeneration of the endothelium at diabetes mellitus. Endokrinolohiya. 2018; 23(4): 384-90.
6. Кузнецова АС, Гоженко АИ, Кузнецова ЕС, Шухтин ВВ, Кузнецова ЕН, Кузнецов СГ. Эндотелий. Физиология и патология: монография. Одесса: «Феникс», 2018. 284 с. (Kuznetsova AS, Gozhenko AI, Byts TM, Bobryk LM, Kuznetsova OM, Kuznetsova SG. Endothelium. Physiology and pathology: monograph. Odessa: Phoenix, 2018. 284 p.).
7. Гоженко АИ, Кузнецова АС, Кузнецова ЕС, Быць ТН, Сусла А.Б. Эндотелиальная дисфункция в патогенезе осложнений сахарного диабета. Сообщение I. Эндотелиальная дисфункция: этиология, патогенез и методы диагностики. Ендокринологія. 2017; 22 (2): 171-81. (Gozhenko AI, Kuznetsova AS, Kuznetsova ES, Byts TN, Susla AB. Endothelial dysfunction in the pathogenesis of diabetes complications. Report I. Endothelial dysfunction: etiology, pathogenesis and diagnostic methods. Endokrinologiya. 2017; 22 (2): 171-81).
8. Гоженко АИ, Кузнецова АС, Кузнецова ЕС, Кузнецова ЕН, Быць ТН, Жуков В. Морфо-функциональные основы эндотелиальной дисфункции при сахарном диабете. J Educ, Health and Sport. 2017; 7(6): 516-24. (Gozhenko AI, Kuznetsova AS, Kuznetsova YeS, Kuznetsova YeN, Byts TN, Zhukov B. Morpho-functional basis of endothelial dysfunction in diabetes mellitus. J Educ, Health and Sport. 2017;7(6):516-24).
9. https://www.plotus.xyz/ Программа анализа и визуализации данных.
10. Шафран ЛМ, Третьякова ОВ, Потапов ЄА, винахідники; Шафран ЛМ, Третьякова ОВ, Потапов ЄА, патентовласники. Спосіб визначення ендотеліальної дисфункції. Патент України № 125773. 2018 трав. 25.
11. Кузнецова АС, Кузнецова ЕС, Быць ТН, Кузнецова ЕН, Демидов СМ, Поветкина ТН, Гоженко АИ. Характеристики эндотелиальной дисфункции у больных сахарным диабетом. Актуальные проблемы транспортной медицины. 2018; 2(52): 116-22. (Kuznetsova AS, Kuznetsova YES, Byts’ TN, Kuznetsova
YеN, Demidov SM, Povetkina TN, Gozhenko AI. Characteristics of endothelial dysfunction in patients with diabetes mellitus. Aktual’nyye problemy transportnoy meditsiny. 2018; 2(52): 116-22).