Study of association of 49A/G polymorphism of gene CTLA4 in patients with latent autoimmune diabetes of adults
Vol. 19 No. 2 (2014), ORIGINAL PAPERS
Vol. 19 No. 2 (2014)

Study of association of 49A/G polymorphism of gene CTLA4 in patients with latent autoimmune diabetes of adults

ORIGINAL PAPERS
Published June 15, 2014
T.M. Tykhonova
State Institution «V.Ya. Danilevsky Institute for Endocrine Pathology Problems, Natl Acad. Med. Sci. of Ukraine»
S.A. Shtande
State Institution «V.Ya. Danilevsky Institute for Endocrine Pathology Problems, Natl Acad. Med. Sci. of Ukraine»
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Keywords

49A/G single nucleotide polymorphism of CTLA4 gene
latent autoimmune diabetes of adults
type 1 and 2 diabetes mellitus

How to Cite

Tykhonova, T., & Shtande, S. (2014). Study of association of 49A/G polymorphism of gene CTLA4 in patients with latent autoimmune diabetes of adults. Endokrynologia, 19(2), 106-110. Retrieved from https://endokrynologia.com.ua/index.php/journal/article/view/257
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Abstract

The authors have studied a single nucleotide 49A/G polymorphism of CTLA4 gene in 44 healthy residents of Kharkov, 109 individuals with latent autoimmune diabetes of  adults (LADA), 64 patients with a classical clinical form of type 1 diabetes mellitus, and 127 patients with type 2 diabetes mellitus. It has been shown that 49A/G  polymorphism of CTLA4 gene - as in type 1 diabetes mellitus - plays an important role in genetic predisposition to LADA in Ukrainian population. A more significant  polymorphism association with LADA - compared with type 2 diabetes - was shown as well.

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Copyright (c) 2014 SI ≪V.P. Komisarenko Institute of Endocrinology and Metabolism, Natl. Acad. Med. Sci. of Ukraine≫

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