Serum levels of adhesion molecules, E-selectin and endothelium-dependent dilation in childhood-onset type 1 diabetic patient with microangiopathy and obese adolescents

Abstract

Aim. To investigate serum levels of adhesion molecules, E-selectin and endothelium-dependent dilation in childhood-onset type 1 diabetic patient with microangiopathy and obese adolescents and the relationship of these factors to the endothelium-dependent dilation. Metods. We examined 30 childhood-onset type 1  diabetic patient with microangiopathy, 30 obese adolescents, 28 control subjects. Serum levels of adhesion molecules, E-selectin were determined by  immunoenzyme assay. Results. We found an elevation serum level of ICAM-1, VCAM-1, E-selectin in childhood-onset type 1 diabetic patient with microangiopathy and  in obese adolescents, which correlated with carbohydrate and lipid metabolism, insulin resistance. Established weakening endothelium-dependent dilation in studied  patients, which correlated with serum level of ICAM-1, VCAM-1, E-selectin. Conclusion. These data suggest the development of endothelial dysfunction in type 1  diabetes and obesity and the possible relationship CAM-1, VCAM-1, E-selectin with these disorders.