The impact of Taurine-containing drug Kratal on heart mitochondria oxidative status in rats with metabolic syndrome

Abstract

The purpose of the present investigation was to evaluate Kratal impact on heart mitochondria oxidant status of rats with metabolic syndrome induced by high fructose  diet. Methods. Assay of glucose homeostasis, reduced glutathione content, Mn-dependent superoxide dismutase, glutathione peroxidase activity, and lipid  peroxides’ level in a suspension of isolated mitochondria. Results. It has been established an abnormal glucose tolerance, an increase in lipid peroxides’ content and a  decrease in reduced glutathione level in animals with metabolic syndrome. Kratal use inhibits insulin resistance and glucose intolerance development, decreases  fructose amine concentration in blood serum, lowers lipid peroxides content, and normalizes reduced glutathione level in heart mitochondria. Conclusions. Kratal  improves insulin sensitivity and prevents oxidative stress development in mitochondria of cardiomyocytes of rats with metabolic syndrome. The detected  pharmacological properties of Kratal suggest the advisability of its use for the prevention and treatment of cardiovascular pathology in the presence of metabolic  syndrome.