Level of proinflammatory cytokines in serum of patients with diabetes mell itus type 1 and type 2 w ith diabetic arthropathy

Abstract

. Joint damage in patients with diabetes mellitus (DM) is a common complication and is associated with the appearance of intraperitoneal-dystopic changes in the periosteal structures. The aim of our work was to study the level of proinflammatory cytokines in patients with diabetic arthropathy and to investigate their possible effect on the development of this complication. Material and methods. 118 patients were examined, which were divided into groups by type of diabetes, the presence and severity of diabetic arthropathy. The content of IL‑1, TNF-α, IL‑6 and receptors to S IL‑6R in serum was determined by immunoassay. Results. In patients with diabetic arthropathy, levels of TNF-α (with type 1 diabetes 44.5%, type 2 diabetes 42.9%) and ІЛ‑6 (with type 1 diabetes 52.1%, with diabetes 2 types by 64.4%) significantly increased. There is a direct correlation between the severity of joint damage and the level of TNF-α and IL‑6. For IL-1, receptors for S IL‑6R have not been detected. Conclusions. The chances of detecting arthropathy with type 1 diabetes with increasing TNF levels increase by 1.7 times, with an increase in IL‑6 by 1.5 times. For type 2 diabetes, it is 1.8 and 1.3 times, respectively. Thus, TNF-α and IL‑6 may be markers of the presence and progression of arthropathy in patients with diabetes mellitus