Expression of protein kinase p70S6K in leukocytes of patients with cancer and diabetes mellitus

Abstract

Aim — to study the expression of p70S6K in leukocytes of patients with cancer and diabetes. Material and methods. P70S6K expression was determined using immune-enzyme analysis. Results. It has been shown that in the leukocytes of patients with cancer and type 2 diabetes, the amount of protein kinase increases, indicating an increase in the expression of p70S6K, which plays an important role in the formation of insulin resistance and tumor progression. However, in the leukocytes of patients with both cancer and diabetes, the amount of p70S6K is significantly reduced compared with the leukocytes of patients with cancer or diabetes. Conclusion. Possible mechanisms and the significance of p70S6K expression in leukocytes are discussed.