Actual aspects of insulin therapy in patients with diabetes mellitus
Vol. 21 No. 2 (2016), ORIGINAL PAPERS
Vol. 21 No. 2 (2016)

Actual aspects of insulin therapy in patients with diabetes mellitus

ORIGINAL PAPERS
Published June 30, 2016
M.D. Tronko
State institution «V. P. Komisarenko Institute of Endocrinology and Metabolism, Nat. Acad. Med. Sci. of Ukraine»
Yu.I. Karachenzev
SI «V.Ya. Danilevsky Institute of Endocrine Pathology Problems, Nat. Acad. Med. Sci. of Ukraine»
L.K. Sokolova
State institution «V. P. Komisarenko Institute of Endocrinology and Metabolism, Nat. Acad. Med. Sci. of Ukraine»
N.O. Kravchun
SI «V.Ya. Danilevsky Institute of Endocrine Pathology Problems, Nat. Acad. Med. Sci. of Ukraine»
Pdf (Українська)

Keywords

diabetes mellitus, insulin therapy

How to Cite

Tronko, M., Karachenzev, Y., Sokolova, L., & Kravchun, N. (2016). Actual aspects of insulin therapy in patients with diabetes mellitus. Endokrynologia, 21(2), 100-106. Retrieved from https://endokrynologia.com.ua/index.php/journal/article/view/121
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Abstract

The results of open randomized clinical trials evaluating the therapeutic equivalence of Insular Active and Insular Stabile insulin compared with the reference drugs Humulin® Regular and Humulin® NPH during the substitution treatment of diabetes are discussed in the article. The following parameters have been evaluated: the changes in the level of glycosylated hemoglobin (HbA1c) at day 90 compared to baseline, the dynamics of the average daily dose of insulin for 3 days and the number of antibodies to insulin in the 90th day of the study compared with baseline. It has been found that the Insular Active and Insular Stabile were therapeutically equivalent to the reference drugs in terms of studied parameters.

Pdf (Українська)

References

1. Гульчий М., Замолотова К., Соколова Л. Системний контроль глікозильованого гемоглобіну — шлях до покращення лікування і якості життя людей з цукровим діабетом // Діабет. Ожиріння. Метаболічний синдром. — 2014. — № 4. — С. 91-98. (Gulchiy M., Zamolotova K., Sokolova L. System control of glycоsylаtеd hеmоglоbіn — a way to improve the treatment and quality of life in people with diabetes mellitus // Diabet. Ozhirennia. Metabolichniy syndrom. — 2014. — № 4. — P. 91-98).
2. Ефимов А.С., Маньковский Б.Н., Костюк Е.П. Актуальные вопросы лечения сахарного диабета и его осложнений // Журн. АМН України. — 2000. — № 3. — С. 471-484. (Yefimov A.S., Mankovsky B.N., Kostyuk E.P. Actual questions of diabetes treatment and its complications // J. AMS Ukraini. — 2000. — № 3. — P. 471-484).
3. Тронько Н.Д., Соколова Л.К., Ковзун Е.И., Пастер И.П. Инсулинотерапия: вчера, сегодня, завтра. — К.: Медкнига, 2014. — 192 c. (Tronko N.D., Sokolova L.K., Kovzun E.I., Pasteur I.P. Insulin therapy: yesterday, today and tomorrow. — K.: Medknyha, 2014. — 192 p.).
4. Swinnen S., Hoekstra J., DeVries H. Insulin therapy for type 2 diabetes // Diabetes Care. — 2009. — № 32. — S253-S259.
5. Subramaniam G., Achike F., Mustafa M. Characterizing the mechanisms of insulin vasodilatation of normal and streptozotocin-induced diabetic rat aorta // J. Cardiovascular Pharmacology. — 2009. — № 53. — P. 333-340.
6. Fendri S., Roussel B., Lormeau B. Insulin sensitivity, insulin action, and fibrinolysis activity in nondiabetic and diabetic obese subjects // Metabolism. — 1998. — № 11. — P. 1372-1375.
7. Trovati M., Anfossi G., Cavalot F. Insulin directly reduces platelet sensitivity to aggregating agents. Studies in vitro and in vivo // Diabetes. — 1988. — № 37. — P. 780-786.

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