Structural and metabolic features of endometrium structure in late reproductive aged women with benign thyropathies

Abstract

The purpose of work is to study the structural and metabolic features of hyperplastic processes of late reproductive aged women with benign thyropathies and to assess the correlation between the histological status and parameters of endometrial morphometry in this contingent of women. Results and discussion. Endometrial hyperplastic processes cause menometrorrhagia nearly in 40% of late reproductive aged women. Menstrual cycle disorders are leading clinical symptom of disease and the main motive for seeking medical advice and hospitalization. Disorders of hormonal homeostasis with changes in growth and differentiation of endometrial cellular elements have significant role among
the reasons of endometrial hyperplasia (ET) the development. Part of thyropathies consists of nearly 50-65% in the structure of associated extragenital diseases in women with ET. It is supposed that the gonadotropin-releasing hormone (GnRH) can play the role of autocrine regulator in the proliferation of carcinoma cell lines, as well as GnRH agonists can cause desensitization or inhibition of GnRH receptors synthesis, providing a direct anti-proliferative effect and thus preventing tumor growth. The structural and metabolic characteristics of endometrial hyperplastic processes in late reproductive aged womenwith benign thyropathies were studied for improving algorithm of examination, prediction and prevention
of developing the pathological endometrial proliferative processes. Conclusions. The time of endometrial condition observation in late reproductive aged women with uterine hyperplastic processes and thyroid pathology should be at least 1 year after the completion of therapy with GnRH agonists. Complicated endometrial hyperplasia
is a factor of greater risk of endometrial malignancy.