Expression level of transcripti on factor c-fos in rat adrenal glands under inhibition of angi otensin-converting enzyme activity in the structures of the hypothalamic-pituitary-adrenocorti cal system
Vol. 22 No. 4 (2017), ORIGINAL PAPERS
Vol. 22 No. 4 (2017)

Expression level of transcripti on factor c-fos in rat adrenal glands under inhibition of angi otensin-converting enzyme activity in the structures of the hypothalamic-pituitary-adrenocorti cal system

ORIGINAL PAPERS
Published December 28, 2017
L.M. Kalynska
SI «V.P. Komissarenko Institute of Endocrinology and Metabolism of Natl. Acad. Med. Sci. of Ukraine»
N.I. Levchuk
SI «V.P. Komissarenko Institute of Endocrinology and Metabolism of Natl. Acad. Med. Sci. of Ukraine»
O.I. Kovzun
SI «V.P. Komissarenko Institute of Endocrinology and Metabolism of Natl. Acad. Med. Sci. of Ukraine»
O.I. Kovzun
SI «V.P. Komissarenko Institute of Endocrinology and Metabolism of Natl. Acad. Med. Sci. of Ukraine»
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Keywords

transcription factor c-fos, angiotensin-converting enzyme (ACE), ACE inhibitors, structures of the hypothalamic-pituitary- adrenocortical system

How to Cite

Kalynska, L., Levchuk, N., Kovzun, O., & Kovzun, O. (2017). Expression level of transcripti on factor c-fos in rat adrenal glands under inhibition of angi otensin-converting enzyme activity in the structures of the hypothalamic-pituitary-adrenocorti cal system. Endokrynologia, 22(4), 336-340. Retrieved from https://endokrynologia.com.ua/index.php/journal/article/view/101
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Abstract

Aim is to study the effect of angiotensin-converting enzyme (ACE) inhibitor perindopril on the expression of the transcription factor c-fos in rat adrenal glands. Methods. The expression level of nuclear transcription factor c-fos in rat adrenal tissue was determined by Western blot analysis. ACE activity in the hypothalamus, the pituitary and the adrenal glands of rats was determined by fluorimetric method. Results. Decrease in ACE activity in regulation centers of the hypothalamic-pituitary-adrenocortical system (HHAS) — in the hypothalamus, the adenohypophysis and the adrenal glands and also in the blood plasma of animals was caused by single administration of ACE inhibitor — perindopril — into intact rats. Increased level of the transcription factor c-fos was revealed in the adrenal glands of rats after perindopril administration. The possible participation of transcription factor c-fos in steroidogenic effects of angiotensin II and ACE is discussed by us. Conclusions. It was shown that a single administration of ACE inhibitor perindopril into intact rats in a dose of 5 mg/kg, that is accompanied by a decrease of ACE activity in regulation centers of HHAS (the hypothalamus, the adenohypophysis and the adrenal glands of animals) and circulating blood enzyme leads to increased transcription factor c-fos in the adrenal glands of animals.

Pdf (Українська)

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