Potassium ions play an important role in the regulation of steroidogenesis, water-salt balance, apoptosis, proliferation. However, the nuclear phase of the agonist signaling in adrenocorticocytes remains poorly understood. The aim of the work was to elucidate the effect of potassium on the level of nuclear transcription factor c-Fos in human tumor adrenocortical tissue (aldosteroma). Methods. Expression of c-Fos transcription factor in aldosteromas was detected using Western-blot analysis. Results. The increase of c-Fos level in human aldosteroma cells at potassium physiological concentration of 3.5 mmol/l compared to medium without potassium was observed. The level of cFos did not change after 8.5 mmol/l K+ administration. The possible participation of transcription factor c-Fos in steroidogenic effects of K+ is being discussed. Conclusions. The results of study suggest that K+ can have a direct effect on the expression level of nuclear transcription factor c-Fos in tissues from human aldosteromas.
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