Анотація
У статті наведено сучасні дані про роль андрогенодефіциту в розвитку вікових захворювань, підвищення рівня смертності в чоловіків і висвітлено проблемні питання замісної тестостеронотерапії.
Посилання
1. Hackett G., Kell P., Ralph D. et al. British Society for Sexual Medicine Guidelines on the Management of Erectile Dysfunction // J. Sex. Med. 2008, 5,1841-1846.
2. Araujo A.B., Durante R., Feldman H.A. et al. The relationship between depressive symptoms and male erectile dysfunction: cross sectional results from the MMAS // Psychosom. Med. 1998, 60, 458-465.
3. Mulligen T., Frick M.F., Zuraw Q.C. et al. Prevalence of hypogonadism in males aged at least 45 years: the HIM study // IJSP. 2006, 60, 762-769.
4. Khaw K.T., Dowsett M., Folkerd E. et al. Endogenous testosterone and mortality due to all causes cardiovascular disease аnd cancer in men: European Prospective Investigation into Cancer in Norfolk (EPIC-NORFOLK) prospective population study // Circulation. 2007, 16, 2694-2701.
5. Shores M.M., Matsumoto A.M., Sloan K.L. et al. Lоw serum testosterone and mortality in male veterans // Arch. Intern. Med. 2006, 166, 1660-1665.
6. Laughlin G.A., Barret-Connor E., Bergstrom J. Low serum testosterone and mortality in older men // J. Clin. Endocrinol. Metab. 2008, 93, 68-75.
7. Лучицький Є.В. Андрогендефіцитний стан у чоловіків, хворих на цукровий діабет 2 типу // Ендокринологія. 2012, 17, №. 2, 28-36.
8. Muller M., Grobbee D.E., den Tonkelaar I. et al. Endogenous sex hormones and metabolic syndrome in aging men // J. Clin. Endocrinol. Metab. 2005, 90, 2618-2623.
9. Gomula A. Late-onset hypogonadism – new point of view. Chapter 6. In: Sex Hormones. Ed. R.K. Dubey. Medan. 2012.
10. Tsai H.K., D’Amico A.V., Sadetsky N. et al. Androgen deprivation therapy for localized prostate cancer and the risk of cardiovascular mortality // J. Natl. Cancer Inst. 2007, 99, 1516-1524.
11. Gray A., Feldman H.A., McKinlay J.B., Longcope C. Age and changing sex hormone levels in middle-aged men: results of the Massachusetts male aging study // J. Clin. Endocrinol. Metab. 1991, 73, 1016-1025.
12. E. Luchytskyy, V. Luchytskyy. Androgendeficiency in males with type 2 diabetes mellitus // J. Sex. Med. 2012, 4, N 2, 78.
13. Gomula A., Rabijewski M. Testosterone deficiency syndrome – diagnosis and treatment – based on age-related testosterone referent levels // Polish Sexol. 2010, 8, 1-16.
14. Zitzmann M., Faber S., Nieshlag E. Association of specific symptoms and metabolic risks with serum testosterone in older men // J.Clin.Endocrinol. Metab. 2006, 91, 4335-4343.
15. Lasarou S., Reyes-Vallejo L., Morgentaler A. Wide variability in laboratory reference values for serum testosterone // J. Sex. Med. 2006, 3, 1085-1089.
2. Araujo A.B., Durante R., Feldman H.A. et al. The relationship between depressive symptoms and male erectile dysfunction: cross sectional results from the MMAS // Psychosom. Med. 1998, 60, 458-465.
3. Mulligen T., Frick M.F., Zuraw Q.C. et al. Prevalence of hypogonadism in males aged at least 45 years: the HIM study // IJSP. 2006, 60, 762-769.
4. Khaw K.T., Dowsett M., Folkerd E. et al. Endogenous testosterone and mortality due to all causes cardiovascular disease аnd cancer in men: European Prospective Investigation into Cancer in Norfolk (EPIC-NORFOLK) prospective population study // Circulation. 2007, 16, 2694-2701.
5. Shores M.M., Matsumoto A.M., Sloan K.L. et al. Lоw serum testosterone and mortality in male veterans // Arch. Intern. Med. 2006, 166, 1660-1665.
6. Laughlin G.A., Barret-Connor E., Bergstrom J. Low serum testosterone and mortality in older men // J. Clin. Endocrinol. Metab. 2008, 93, 68-75.
7. Лучицький Є.В. Андрогендефіцитний стан у чоловіків, хворих на цукровий діабет 2 типу // Ендокринологія. 2012, 17, №. 2, 28-36.
8. Muller M., Grobbee D.E., den Tonkelaar I. et al. Endogenous sex hormones and metabolic syndrome in aging men // J. Clin. Endocrinol. Metab. 2005, 90, 2618-2623.
9. Gomula A. Late-onset hypogonadism – new point of view. Chapter 6. In: Sex Hormones. Ed. R.K. Dubey. Medan. 2012.
10. Tsai H.K., D’Amico A.V., Sadetsky N. et al. Androgen deprivation therapy for localized prostate cancer and the risk of cardiovascular mortality // J. Natl. Cancer Inst. 2007, 99, 1516-1524.
11. Gray A., Feldman H.A., McKinlay J.B., Longcope C. Age and changing sex hormone levels in middle-aged men: results of the Massachusetts male aging study // J. Clin. Endocrinol. Metab. 1991, 73, 1016-1025.
12. E. Luchytskyy, V. Luchytskyy. Androgendeficiency in males with type 2 diabetes mellitus // J. Sex. Med. 2012, 4, N 2, 78.
13. Gomula A., Rabijewski M. Testosterone deficiency syndrome – diagnosis and treatment – based on age-related testosterone referent levels // Polish Sexol. 2010, 8, 1-16.
14. Zitzmann M., Faber S., Nieshlag E. Association of specific symptoms and metabolic risks with serum testosterone in older men // J.Clin.Endocrinol. Metab. 2006, 91, 4335-4343.
15. Lasarou S., Reyes-Vallejo L., Morgentaler A. Wide variability in laboratory reference values for serum testosterone // J. Sex. Med. 2006, 3, 1085-1089.
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