Keywords
anti-ovarian antibodies
thyroid peroxidase antibodies
thyroglobulin antibodies
ovarian reserve
anti-Müllerian hormone
prolactin
How to Cite
Abstract
Autoimmune thyroiditis is often associated with systemic
immune dysregulation that may potentially affect reproductive
function. The aim of this study was to evaluate the levels of
thyroid peroxidase antibodies (TPOAb), thyroglobulin antibodies
(TgAb), and anti-ovarian antibodies (AOA) in women with autoimmune
thyroiditis, as well as to investigate the impact of antithyroid
and anti-ovarian antibodies on reproductive function parameters,
including anti-Müllerian hormone (AMH), antral follicle count (AFC),
and prolactin levels. Material and methods. This two-center analytical
study included 107 women with autoimmune thyroiditis and
20 women of control group. Serum levels of TPOAb, TgAb, AOA,
thyroid-stimulating hormone (TSH), free thyroxine (fT4), AMH, and
prolactin were measured, and the antral follicle count was assessed.
Results. Women with autoimmune thyroiditis demonstrated significantly
higher AOA levels compared with controls (11.49±0.88
vs 4.46±0.63 U/L; p<0.05), along with elevated prolactin concentrations
(19.84±1.72 vs 13.00±1.79 ng/mL; p<0.05). AMH and CAF levels
did not differ statistically significantly between groups. Correlation
analysis revealed a positive association between AOA levels and
age. No significant correlations were found between AOA and AMH,
CAF, or PRL, as well as between AOA and thyroid status parameters.
No significant correlations were found between the levels of ATP
and PRL, AMH and AOA (p>0.05). Conclusion. In women with AIT,
the level of AOA significantly exceeded that of the control group
(p<0.05), which indicates the systemic nature of the autoimmune
process with the involvement of the reproductive system. Patients
with autoimmune thyroiditis also showed a statistically significant
increase in PRL levels compared to the control group (p<0.05). No
significant correlations were found between the level of anti-ovarian
antibody and markers of ovarian reserve (AMH, AFC) and PRL,
which indicates the absence of a direct relationship between the
titer of anti-ovarian antibodies and a decrease in ovarian reserve.
No significant correlations were identified between the level ATPO
and PRL, AMH and AFC.
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