Keywords
civilian women
metabolic disorders
psychoemotional disorders
quercetin
prediabetes
dyslipidemia
metabolic age
anxiety
depression
How to Cite
Abstract
Abstract. The presence of the civilian population of Ukraine in conditions of prolonged war stress has led to an increase in the frequency of carbohydrate and lipid metabolism disorders, accelerated metabolic aging, and psycho-emotional disorders. These disorders contribute to the development of cardiometabolic diseases and require effective correction.
Aim. To determine the effects of a course of quercetin (Q) in civilian women with metabolic and psycho-emotional disorders under conditions of prolonged war stress.
Subjects and methods. 65 women aged 40 to 69 years participated in the randomized comparative study. During 2022-2024, they were strongly influenced by the stress factors of the Russian-Ukrainian war. The inclusion criteria for the study were the presence of at least two metabolic disorders (prediabetes, dyslipidemia, accelerated metabolic aging) and at least two other criteria (increased anxiety, depression, sleep disorders). Women in both groups could take as basic therapy (BT) an angiotensin-converting enzyme inhibitor, a statin, acetylsalicylic acid in unchanged doses for at least a month before randomization and during the study. The main group included 33 women who used BT and Q for a month in a daily dose of 240 mg. The comparison group included 32 women who received only BT for a month. Results. In women of the BT and Q groups,
compared with women of the BT group, the level of situational anxiety (p<0.05) and the integral index of sleep disturbance (p<0.05)
decreased, and a tendency to a decrease in the level of depression was also revealed. The addition of Q to BT contributed to a decrease in the percentage of individuals with prediabetes, a statistically significant decrease in plasma glucose concentration after 2 hours of standard glucose tolerance test (GTT), cholesterol (C) and low-density lipoprotein cholesterol (LDL-C) levels, and atherogenic index. In addition, women from the BT and Q groups had a decrease in metabolic age (MA) and metabolic age rate, (MAR) compared with changes in these indicators from the BT group (p<0.05).
Conclusions. The results of the study indicate the possibility of using Q to correct metabolic and psycho-emotional disorders in women exposed
to prolonged war stress.
References
Lushchak O, Velykodna M, Bolman S, Strilbytska O, Berezovskyi V, Storey KB. Prevalence of stress, anxiety, and symptoms of post-traumatic stress disorder among Ukrainians after the first year of Russian invasion: a nationwide cross-sectional study. Lancet Reg Health Eur. 2023 Nov 6;36:100773. doi: 10.1016/j. lanepe.2023.100773.
Kurapov A, Kalaitzaki A, Keller V, Danyliuk I, Kowatsch T. The mental health impact of the ongoing Russian-Ukrainian war 6 months after the Russian invasion of Ukraine. Front Psychiatry. 2023 Jul 27;14:1134780. doi: 10.3389/fpsyt.2023.1134780.
Наскалова СС, Антонюк-Щеглова ІА, Бондаренко ОВ, Асанов ЕО, Диба ІА, Писарук АВ, та ін. Фізіологічний журнал. 2024;70(5):20-9 (Naskalova SS, Antonyuk-Shcheglova IA, Bondarenko OV, Asanov EO, Dyba IA, Pysaruk AV, et al. Markers of Post-Traumatic Stress in Civilian Men and Women of Different Ages During the Russian-Ukrainian War. Fiziol. Zh. 2024; 70(5):20-9. Ukrainian). doi: 10.15407/fz70.05.020.
Шатило ВБ, Наскалова СС, Писарук АВ, Асанов ЕО, Бондаренко ОВ, Кошель НМ, та ін. Вплив стресу, пов’язаного із війною, на стан вуглеводного й ліпідного обмінів та темп метаболічного старіння в жінок різного віку. Ендокринологія. 2024;30(2):148-54 (Shatylo VB, Naskalova SS, Pysaruk AV, Asanov EO, Bondarenko OV, Koshel NM, et al. Effects of war-related stress on the state of carbohydrate and lipid metabolism and the rate of metabolic aging in women of different ages. Endokrynologia. 2024;30(2):148-54. Ukrainian). doi: 10.31793/1680-1466.2024.30-2.148.
Shatylo VB, Naskalova SS, Asanov EO, Pysaruk AV, Bondarenko OV. The impact of post-traumatic stress disorder on indicators of carbohydrate and lipid metabolism, metabolic age of civilian women during war. Endokrynologia. 2025;30(1):39-44. doi: 10.31793/1680-1466.2025.30-1.39.
Peruzzolo TL, Pinto JV, Roza TH, Shintani AO, Anzolin AP, Gnielka V, et al. Inflammatory and oxidative stress markers in post-traumatic stress disorder: a systematic review and meta-analysis. Mol Psychiatry. 2022 Aug;27(8):3150-63. doi: 10.1038/s41380-022-01564-0.
Milaneschi Y, Kappelmann N, Ye Z, Lamers F, Moser S, Jones PB, et al. Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts. Mol Psychiatry. 2021 Dec;26(12):7393-402. doi: 10.1038/s41380-021-01188-w.
Lee DH, Lee JY, Hong DY, Lee EC, Park SW, Lee MR, et al. Neuroinflammation in post-traumatic stress disorder. Biomedicines. 2022 Apr 20;10(5):953. doi: 10.3390/biomedicines10050953.
Winiarska-Mieczan A, Kwiecień M, Jachimowicz-Rogowska K, Donaldson J, Tomaszewska E, Baranowska-Wójcik E. Anti-inflammatory, antioxidant and neuroprotective effects of polyphenols – polyphenols as an element of diet therapy in depressive disorders. Int J Mol Sci. 2023 Jan 23;24(3):2258. doi: 10.3390/ijms24032258.
Ferenczyova K, Kalocayova B, Bartekova M. Potential implications of Quercetin and its derivatives in cardioprotection. Int J Mol Sci. 2020 Feb 26;21(5):1585. doi: 10.3390/ijms21051585.