Keywords
civilian women
prediabetes
dyslipidemia
metabolic age
How to Cite
Abstract
Abstract. The consequences of post-traumatic stress associated with war are not only mental disorders, but also various unfavorable changes in physical functioning, in particular, metabolic disorders. Previous studies have shown an association between posttraumatic stress disorder (PTSD) and obesity, metabolic syndrome, and type 2 diabetes in military veterans. It has also been established that PTSD accelerates the rate of biological aging at the cellular level. However, the impact of PTSD on the frequency and manifestations of metabolic disorders in civilian women remains poorly understood.
Aim. To determine the impact of PTSD on the state of carbohydrate and lipid metabolism, metabolic age (MA), and rate of metabolic aging (RMA) in women during the war. Subjects and methods. During the war, 120 civilian women aged 30-79 years without clinically significant diseases were examined, including 26 with PTSD and 94 without it. Data of 79 women of the same age examined before the war were used for comparison. The examination included analysis of PCL-5 questionnaire, enzyme immunoassay methods for determining cortisol and insulin in blood plasma, biochemical methods for determining glucose and lipids in blood, calculation of MA and RMA.
Results. During the war, women without PTSD, compared with women examined before the war, had higher plasma insulin concentrations and an insulin resistance index, but plasma glucose levels were not yet changed. Women with PTSD, in addition to higher insulin concentrations and an insulin resistance index, had a statistically significantly higher fasting plasma glucose level during the war. In all age groups of women with PTSD during the war, the proportion of people with prediabetes was higher than before the war. Dyslipidemia was more common in young women with PTSD than before the war. In women with PTSD during the war, the RMA increases.
Conclusions. During wartime in women with PTSD develop insulin resistance, which leads to prediabetes disorders of carbohydrate metabolism. In women with PTSD, the frequency of dyslipidemia is higher, the MA increases, and the RMA accelerates compared to the before the war level.
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