Keywords
essential elements (I2, Se, Mg, Zn, Ca)
vitamin D
deficiency
How to Cite
Abstract
Abstract. Deficiency of essential elements is one of the factors for the occurrence and progression of various chronic diseases, including endocrine diseases, in particular type 2 diabetes mellitus (DM2). Understanding the state of provision of certain microelements and
vitamins is important for determining their pathogenetic role in diabetes mellitus (DM) and for developing treatment and preventive
recommendations.
The aim: to determine the consumption of essential elements iodine (I2), selenium (Se), magnesium (Mg), zinc (Zn), calcium (Ca), as well as vitamin D in T2D.
Material and methods. The open-label controlled study involved 71 patients with T2D (52 women and 14 men) aged 39-74 years. The control group consisted of 40 people without endocrine and somatic diseases (30 women and 10 men) aged 38-74 years. The study included people
who had not taken food supplements and vitamin preparations for at least 3 months before the start of the study. The concentration of I2 in urine was determined by the cerium-arsenite method on a «UV-1280» spectrophotometer («Shimadzu», Japan), the Se content in blood serum was determined by the fluorometric method after acid mineralization of samples on a «MPF-4» spectrofluorometer («Hitachi», Japan), the content of Mg, Ca and 25(OH)D was determinedon a «Cobas 6000» analyzer («Roshe Diagnostic», Switzerland), Zn was determined on an atomic absorption spectrophotometer using a «ContrAA 800F», «Analytik Jena», Germany).
Results. In patients with T2D, a deficiency of essential elements was observed (I2 – in 70% of cases, Ca – in 70%, Mg – in 65%, Se – in 50% and Zn – in 66%), as well as vitamin D (in 80% of cases).
Conclusions. A significant decrease in the level of essential elements Ca, Mg, Se and Zn in the blood serum of patients with T2D was revealed. The content of essential elements in the blood serum of patients with T2D significantly correlated with the levels of fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c).
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