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Abstract
Department of Pediatric Endocrine Pathology (DPEP) of the State Institution «V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine», formed almost 50 years ago, today is the leading institution of pediatric endocrinology in Ukraine. The initiative to create a department of pediatric endocrinology in Ukraine was provided by Acad. V.P. Komisarenko and supported by prof. Benikova O.A., who formed the basic principles of Ukrainian clinical pediatric endocrinology. The main direction of scientific researches was studying the pathology of growth and sexual development of children and adolescents, which still remains a priority scientific direction of the DPEP work; however, the emergence of new modern biochemical, hormonal, molecular genetic, instrumental methods of research, experimental studies have led to a fundamentally different level of diagnosis, differential diagnosis, treatment of endocrine pathology in children and adolescence. Since the end of 1989, DPEP was headed by candidate of medical sciences O.V. Bolshova, under whose leadership this direction was further developed. Thus, for the first time in Ukraine, the Registry of patients with short stature caused by growth hormone deficiency (GHD) was created, which made it possible to conduct a thorough study of the etiopathogenesis of GHD in childhood and adolescence, allows obtaining correct data on the number of GHD patients, determining the need for rGH; for the first time in Ukraine, a comprehensive clinical and hormonal study of the state of physical and sexual development was carried out, the mechanisms of stature formation, the features of the functioning of the GH/IGF-1/IGF-BP-3 system in children and adolescents against the background of various endocrine diseases, and the dynamics of changes in these indicators were studied in the process of treatment. For the first time, a comprehensive study of the physical and hormonal condition was performed, the features of ghrelin secretion in children with growth disorders were studied, modern diagnostic algorithms and optimal treatment regimens for prepubertal children with complete and partial GHD, intrauterine growth retardation, idiopathic and familial constitutional short stature, syndrome of biologically inactive growth hormone, were proposed. Effective combined therapy regimens with the use of rGH, zinc preparations and Vit D have been proposed. For the first time, a regimen of therapy with rGH and LH-RH analogues has been proposed. Recent studies are mainly devoted to hormonal and molecular genetic studies of the state of the GH/IGF-1/IGF-BP-3system/vitD/vitD receptor gene polymorphism and the development of modern diagnosis and treatment methods based on the results obtained. In addition, much attention is paid to the study of the features of the etiopathogenesis, clinic and treatment of diabetes mellitus in childhood and adolescence. The results of studies of the state of the thyroid gland in children and adolescents after exposure to ionizing radiation as a result of Chornobyl nuclear power plant are reflected in collective scientific international publications and monographs. Thanks our developments and many years of experience, the DPEP team introduced a large number of new methods of diagnosing and treating various diseases of the endocrine glands in childhood and adolescence into the practice of Ukrainian healthcare. The priority, relevance, and practical significance of these developments are confirmed by patents, monographs, textbooks, manuals, and publications in domestic and international journals.
References
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