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Abstract
Papillary thyroid carcinoma (PTC) is frequent thyroid malignant neoplasm, measuring 1 cm or less in the greatest diameter, and is classifi ed as papillary thyroid microcarcinoma (PTMC). Up to 10% of PTMCs have a biologically aggressive course, manifested by invasive characteristics of the tumor (invasion of blood vessels, lymphatic vessels, perineural invasion, the appearance of mitotic fi gures, etc.), recurrence of carcinoma, which are parameters that are diffi cult to predict. Aim. To study and evaluate the clinical and histopathological features of PTMC in comparison with PTC. Material and methods. There were identifi ed 91 patients with PTC, who underwent surgical treatment at the clinical bases of the Department of Surgery at the Institute of Biology and Medicine of Taras Shevchenko National University. In the studied cohort of 91 patients, 50 (85%) patients were diagnosed with PTMC, and 41 (15%) patients with PTC. Results. Lymphovascular invasion was signifi cantly less often diagnosed in 15 (30%) patients in the PTMC group, compared to 24 (58%) patients in the PTC group (p<0.005). Also, not a single case of perineural invasion of carcinoma was diagnosed in the PTMC group, which is signifi cantly lower compared to 4 (10%) patients in the PTC group (p<0.005). Further analysis of the pathomorphological data also showed a statistically signifi cant diff erence between the data of macroscopic and microscopic carcinoma invasion patterns. Microscopic extrathyroidal extension of carcinoma was less often detected in patients in the PTMC group – 2 (4%) patients, as compared to 12 (29%) patients in the PTC group (p<0.005). It should also be noted that macroscopically, extrathyroidal extension was diagnosed signifi cantly less often in patients in the PTMC group in 1 (2%) patients as compared to 9 (22%) patients in the PTC group (p<0.005). Conslusions. PTMC exhibits lower biologic aggressiveness than PTC, as evidenced by lower rates of microscopic and macroscopic invasion, perineural invasion, and lymphatic invasion. Microcarcinoma may be considered a more favorable prognostic factor for patients with PTC.
References
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