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Abstract
Aim is to study the effect of various treatment schemes with glucocorticoids on the course of autoimmune ophthalmopathy and the level of antibodies to the TSH receptor (antibody to rTSH) in patients with diffuse toxic goiter (DTG). Materials and methods. In total 189 patients with diffuse toxic goiter and autoimmune ophthalmopathy were examined. The blood levels of TSH, thyroid hormones and antibody to rTSH were determined during thyreostatic therapy and treatment by glucocorticoids (comparing
the effectiveness of «alternating» treatment scheme with prednisolone and pulse therapy). Results. When analyzing the dynamics of ophthalmopathy clinical manifestations, the data of ultrasound examination of the orbit tissues, changes in the levels of antibody to rTSH during the course of treatment, it was revealed, that patients with DTG and ophthalmopathy who were taken «alternating» glucocorticoids regimen, kept the more distinct clinical signs of ophthalmopathy and orbit tissue changes (according the sonography data) the level of antibody to rTSH significantly exceeded that of patients treated with metilprednisolone pulse therapy, even in 6 months after treatment. Conclusion. Pulse therapy with prednisolone is more effective and safe comparing with other regimens of therapy.
References
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