Keywords
How to Cite
Abstract
Aim is to study the relationships between the level of the bone tissue hormone, osteocalcin, and constitutional-metabolic phenotypic characteristics in patients with type 2 dіabetes
mellitus. Materials and methods. Generally 44 patients older than 50 years, including 23 men and 21 women in a state of menopause were examined. The level of blood serum osteocalcin and the visceral adiposity index were measured in patients. Results. A significant decrease in the blood osteocalcin level was revealed against a background of increased visceral adiposity. This indicates a significant decrease in osteosynthesis process against a background of constitutional and metabolic disorders resulting in certain phenotypic changes in patients with type 2 diabetes mellitus. At the same time the visceral adiposity index that includes humoral and anthropometric indicators was more accurate unified
parameter of phenotypic changes, comparing to waist circumference index.
References
2. Geetha L., Deepa M., Anjana R.M., Mohan V. Prevalence and clinical profile of metabolic obesity and phenotypic obesity in Asian Indians // J. Diab. Sci. Technol. — 2011. — Vol. 5,
№ 2. — P. 439-446.
3. Sullivan T.R., Duque G., Keech A.C., Herrmann M. An old friend in a new light: The role of osteocalcin in energy metabolism // Cardiovasc. Ther. — 2013. — Vol. 31. — P. 65-75.
4. Yoshizawa T. Bone remodeling and glucose/lipid metabolism // Clin. Caicium. — 2011. — Vol. 21, № 5. — P. 709-714.
5. Wieczorek-Baranowska A., Nowak A., Pilaczyńska-Szcześniak L. Osteocalcin and glucose metabolism in postmenopausal women subjected to aerobic training program for 8 weeks //
Metabolism. — 2012. — Vol. 61, № 4. — P. 542-545.
6. Ruzicska E., Poór G. Diabetes and bone metabolism // Orv. Hetil. — 2011. — Vol. 152, № 29. — P. 1156-1160.
7. Villafán-Bernal J.R., Sánchez-EnrÍquez S., Muñoz-Valle J.F. Molecular modulation of osteocalcin and its relevance in diabetes (Review) // Int. J. Mol. Med. — 2011. — Vol. 28, № 3. — P. 283-293.
8. Zanatta L.C., Boguszewski C.L., Borba V.Z., Kulak C.A. Osteocalcin, energy and glucose metabolism // Arq. Bras. Endocrinol. Metabol. — 2014. — Vol. 58, № 5. — P. 444-451.
9. Liu C., Wo J., Zhao Q., Wang Y., Wang B., Zhao W. Association between serum total osteocalcin level and type 2 diabetes mellitus: A systematic review and meta-analysis // Horm. Metab. Res. — 2015. — Vol. 47, № 11. — P. 813-819.
10. Zhou M., Ma X., Li H., Pan X., Tang J., Gao Y., Hou X., Lu H., Bao Y., Jia W. Serum osteocalcin concentrations in relation to glucose and lipid metabolism in Chinese individuals // Eur.
J. Endocrinol. — 2009. — Vol. 161, № 5. — P. 723-729.
11. Saleem U., Mosley T.H., Kullo I.J. Serum osteocalcin is associated with measures of insulin resistance, adipokine levels, and the presence of metabolic syndrome // Arterioscler. Thromb. Vasc. Biol. — 2010. — Vol. 30, № 7. — P. 1474-1478.
12. Kanazawa I., Yamaguchi T., Tada Y., Yamauchi M., Yano S., Sugimoto T. Serum osteocalcin level is positively associated with insulin sensitivity and secretion in patients with type 2
diabetes // Bone. — 2011. — Vol. 48, № 4. — P. 720-725.
13. Hwang Y.C., Jeong I.K., Ahn K.J., Chung H.Y. Circulating osteocalcin level is associated with improved glucose tolerance, insulin secretion and sensitivity independent of the plasma
adiponectin level // Osteoporos Int. — 2012. — Vol. 23, № 4. — P. 1337-1342.
14. Bao Y.Q., Zhou M., Zhou J., Lu W., Gao Y.C., Pan X.P., Tang J.L., Lu H.J., Jia W.P. Relationship between serum osteocalcin and glycaemic variability in Type 2 diabetes // Clin. Exp. Pharmacol. Physiol. — 2011. — Vol. 38, № 1. — P. 50-54.