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Abstract
On April 26, 1986, the largest man-made accident in the history of mankind was happened at the fourth reactor of the Chernobyl Nuclear Power Plant (ChNPP). Aim is to present information about clinical trials on the medical consequences of the accident at the ChNPP is presented. Results. As of March 31, 2020, the information about 6 clinical trials on the medical consequences of the Chornobyl accident was posted at ClinicalTrials.gov. The average duration of clinical trials is 15 years and 9 months, and 2/3 of them have been performed for more than 20 years. Current status of clinical trials: «completed» — 3 trials, «recruiting» — 1 trial, «active, not recruiting» — 1 trial, and «terminated» — 1 trial. 4 clinical trials are conducted in Ukraine: 3 — on the basis of the SI «National
Scientific Center for Radiation Medicine, Natl. Acad. Med. Sci. of Ukraine» and 1 — on the basis of the SI «V.P. Komissarenko Institute of Endocrinology and Metabolism, Natl. Acad. Med. Sci. of Ukraine»; 1 clinical trial is conducted in the Republic of Belarus on the basis of the Republican Scientific and Practical Center for Radiation Medicine and Human Ecology (Gomel), and 1 completed clinical trial was conducted in the United States on the basis of the National
Cancer Institute. In all clinical trials, the main researcher is an employee of the National Cancer Institute (USA). The sponsor of all clinical trials is the National Cancer Institute (USA). The total number of participants in clinical trials was 51 051 people (minimum — 673, maximum — 23 143, average — 8 508). The type of study in all clinical trials was observational. The distribution by research model is as follows: cohort study — 2 trials, case-control studies — 2 trials,
family-based — 1 trial (no information is available for one trial). For the time perspective, the clinical trials were retrospective — 3 trials, prospective — 1 trial, and cross-sectional — 1 trial (no information is available for one trial). According to the sampling method, clinical trials were random (2 trials) and non-random (3 trials); no information is available for one trial. A review of 20 publications based on the results of 5 clinical trials is presented. Conclusion. An extremely
small number of clinical trials of the medical consequences accident at the ChNPP are registered at the website ClinicalTrials. gov registered.
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