Keywords
2 type diabetes, gender peculiarities, age-related peculiarities, testosterone, dehydroepiandrosterone sulfate, sex hormone binding globulin.
How to Cite
Korpacheva-Zinych, L., & Korpacheva, T. (2012). Gender and age-related peculi arities of interrelations between dehydroepiandrosterone sulfate and androgen supplying in 2 type diabetic patients. Endokrynologia, 17(4), 65-73. Retrieved from https://endokrynologia.com.ua/index.php/journal/article/view/427
Abstract
A parallel decrease of dehydroepiandrosterone sulfate (DHEA-S) and free testosterone (T) serum levels have been established in type 2 diabetic men. Higher DHEA-S levels in patients have corresponded to lower SHBG and to higher free T serum concentrations, as well as to higher DHEA-S/T ratios. Low DHEA-S concentrations have associated with increased SHBG levels (especially in men), decreased free T level, and lower DHEA-S/T ratios regardless of sex. This may indicate more intensive conversion of DHEA-S into T both in men and women. Gender differences have been presented as higher SHBG levels in men from low deciles of DHEA-S, while in women these changes have been absent. It is assumed that decreasing of total T and cortisol levels in women may be related to
declining of testosterone formation from adrenal precursors in conditions of adrenopause development.
References
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6. Haren M.T., Malmstrom T.K., Banks W. et al. Lower serum DHEAS levels are associated with a higher degree of physical disability and depressive symptoms in middleaged to older African American women. // Maturitas. 2007, 57, N4, 347-360.
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8. Wong S.Y., Leung J.C., Kwok T. et al. Low DHEAS levels are associated with depressive symptoms in elderly Chinese men: results from a large study // Asian J. Androl. 2011, 13, N 6, 898-902.
9. Cappola A.R., O’Meara E.S., Guo W. et al. Trajectories of dehydroepiandrosterone sulfate predict mortality in older adults: the cardiovascular health study // J. Gerontol. Biol. Sci. Med. Sci. 2009, 64, N 12, 1268-1274.
10. Johannes C.B., R.K. Stellato, H.A. Feldman et al. Relation of dehydroepiandrosterone and dehydroepiandrosterone sulfate with cardio-vascular disease risk factors in women: longitudinal results from the Massachusetts Women’s Health Study // J. Clin. Epidemiol. 1999, 52, 95–103.
11. Liu P.Y., Wishart S.M., Celermajer D.S. et al.. Do reproductive hormones modify insulin sensitivity and metabolism in older men? A randomized, placebo-controlled clinical trial of recombinant human chorionic gonadotropin // Eur. J. Endocrinol. 2003, 148, 55–66.
12. Bjornerem A., Straume B., Midtby M. et al. Endogenous sex hormones in relation to age, sex, lifestyle factors, and chronic diseases in a general population: the Tromso Study // J. Clin.Endocrinol. Metab. 2004, 89, 6039–6047.
13. Stellato R.K, Feldman H.A., Hamdy O. et al. Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts Male Aging Study. // Diabetes Care. 2000, 23, 490-494.
14. Haffner S.M. Sex hormones, obesity, fat distribution, type 2 diabetes and insulin resistance: epidemiological and clinical correlation // Int. J. Obes. Relat. Metab. Disord. 2000, 24, Suppl 2, S56-S58.
15. Laughlin G.A., Barrett-Connor E. Sexual dimorphism in the influence of advanced aging on adrenal hormone levels: The Rancho Bernardo Study // J. Clin. Endocrinol. Metab. 2000, 85, 3561-3568.
2. Schoorlemmer R.M., Peeters G.M., van Schoor N.M., Lips P. Relationships between cortisol level, mortality and chronic diseases in older persons // Clin. Endocrinol. 2009, 71, N 6, 779–786.
3. Cooper M.S., Stewart P.M. 11β-Hydroxysteroid Dehydrogenase type 1 and its role in the hypothalamus-pituitary-adrenal axis, metabolic syndrome, and inflammation // J. Clin. Endocr. Metab. 2009, 94, N 12, 4645-4654.
4. Гончаров Н.П., Кация Г.В. Гормон здоровья и долголетия. М.: Изд-во «Адамант», 2012. 158 с.
5. Labrie F. DHEA, important source of sex steroids in men and even more in women // Prog. Brain Res. 2010, 182, 97-148.
6. Haren M.T., Malmstrom T.K., Banks W. et al. Lower serum DHEAS levels are associated with a higher degree of physical disability and depressive symptoms in middleaged to older African American women. // Maturitas. 2007, 57, N4, 347-360.
7. Tchernof A., Labrie F. Dehydroepiandrosterone, obesity and cardiovascular disease risk: a review of human studies // Eur. J. Endocrinol. 2004, 151, 1–14.
8. Wong S.Y., Leung J.C., Kwok T. et al. Low DHEAS levels are associated with depressive symptoms in elderly Chinese men: results from a large study // Asian J. Androl. 2011, 13, N 6, 898-902.
9. Cappola A.R., O’Meara E.S., Guo W. et al. Trajectories of dehydroepiandrosterone sulfate predict mortality in older adults: the cardiovascular health study // J. Gerontol. Biol. Sci. Med. Sci. 2009, 64, N 12, 1268-1274.
10. Johannes C.B., R.K. Stellato, H.A. Feldman et al. Relation of dehydroepiandrosterone and dehydroepiandrosterone sulfate with cardio-vascular disease risk factors in women: longitudinal results from the Massachusetts Women’s Health Study // J. Clin. Epidemiol. 1999, 52, 95–103.
11. Liu P.Y., Wishart S.M., Celermajer D.S. et al.. Do reproductive hormones modify insulin sensitivity and metabolism in older men? A randomized, placebo-controlled clinical trial of recombinant human chorionic gonadotropin // Eur. J. Endocrinol. 2003, 148, 55–66.
12. Bjornerem A., Straume B., Midtby M. et al. Endogenous sex hormones in relation to age, sex, lifestyle factors, and chronic diseases in a general population: the Tromso Study // J. Clin.Endocrinol. Metab. 2004, 89, 6039–6047.
13. Stellato R.K, Feldman H.A., Hamdy O. et al. Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts Male Aging Study. // Diabetes Care. 2000, 23, 490-494.
14. Haffner S.M. Sex hormones, obesity, fat distribution, type 2 diabetes and insulin resistance: epidemiological and clinical correlation // Int. J. Obes. Relat. Metab. Disord. 2000, 24, Suppl 2, S56-S58.
15. Laughlin G.A., Barrett-Connor E. Sexual dimorphism in the influence of advanced aging on adrenal hormone levels: The Rancho Bernardo Study // J. Clin. Endocrinol. Metab. 2000, 85, 3561-3568.
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