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Abstract
The effect of anti-cancer drug paclitaxel on the cells resistant to the drug thyroid cancer lines KTC-3 and ARO has been studied. It has been shown that in the presence of paclitaxel activation of apoptotic processes in the tumor cells KTC-3 observes in 18 h after start of incubation. A possible reason for the resistance of the KTC-3 cells to paclitaxel is delayed, compared with the cells of more sensitive lines, activation of apoptotic processes, and a decrease in the activity of antiapoptotic cascade cRaf/ERK, activation of the transcription factor ATF-2 and cell cycle arrest may be a triggering mechanizm of such activatoin. Resistance of the ARO cell line compared to the KTC-2 cell line may be due to mutation of the TP53 gene, which causes insufficient production of p21WAF1 inhibitor and as a result absence of cell cycle arrest.
References
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