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Abstract
The author has studied the effect of different methanandamide concentrations on the intensity of internucleosomal DNA fragmentation in adrenal tissue of male and female rats. The drug at a concentration of 10-8-10-6 M was shown to lead to a decreased intensity of internucleosomal DNA fragmentation in male and female rats in vitro. One peculiarity of methanandamide impact on the intensity of DNA fragmentation in rats of different gender is a differently directed
effect of the drug on the content of oligonucleosomes of different size (the levels of fragments measuring 200 bp was reduced in males, the content of mononucleosomes was increased in females, and the levels of di-, tri- and tetranucleosomes was decreased), which can be due to estrogens effect. The mechanisms of estrogen involvement in the realization of methanandamide effect are under discussion.
References
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