Immunity in patients w ith type 2 diabetes mellitus in complex w ith concomitant metabolic syndrome/obesity. Communication 2. Role of adipocytokines (interleukin-6, tumor necrosis factor alpha, leptin and adiponectin)
Vol. 18 No. 2 (2013), ORIGINAL PAPERS
Vol. 18 No. 2 (2013)

Immunity in patients w ith type 2 diabetes mellitus in complex w ith concomitant metabolic syndrome/obesity. Communication 2. Role of adipocytokines (interleukin-6, tumor necrosis factor alpha, leptin and adiponectin)

ORIGINAL PAPERS
Published June 20, 2013
K.P. Zak
ДУ «Інститут ендокринології та обміну речовин ім. В.П. Комісаренка НАМН України»
B.M. Mankovsky
ДУ «Інститут ендокринології та обміну речовин ім. В.П. Комісаренка НАМН України»
S.V. Melnichenko
ДУ «Інститут ендокринології та обміну речовин ім. В.П. Комісаренка НАМН України»
I.M. Kondratska
ДУ «Інститут ендокринології та обміну речовин ім. В.П. Комісаренка НАМН України»
V.V. Popova
ДУ «Інститут ендокринології та обміну речовин ім. В.П. Комісаренка НАМН України»
Ya.A. Sayenko
ДУ «Інститут ендокринології та обміну речовин ім. В.П. Комісаренка НАМН України»
T.A. Semionova
ДУ «Інститут ендокринології та обміну речовин ім. В.П. Комісаренка НАМН України»
O.V. Korpacheva-Zinych
ДУ «Інститут ендокринології та обміну речовин ім. В.П. Комісаренка НАМН України»
K.M. Tronko
ДУ «Інститут ендокринології та обміну речовин ім. В.П. Комісаренка НАМН України»
O.V. Furmanova
ДУ «Інститут ендокринології та обміну речовин ім. В.П. Комісаренка НАМН України»
pdf (Українська)

Keywords

immunity, type 2 diabetes mellitus, metabolic syndrome, obesity, interleukin-6, tumor necrosis factor alpha, leptin, adiponectin, peripheral blood.

How to Cite

Zak, K., Mankovsky, B., Melnichenko, S., Kondratska, I., Popova, V., Sayenko, Y., Semionova, T., Korpacheva-Zinych, O., Tronko, K., & Furmanova, O. (2013). Immunity in patients w ith type 2 diabetes mellitus in complex w ith concomitant metabolic syndrome/obesity. Communication 2. Role of adipocytokines (interleukin-6, tumor necrosis factor alpha, leptin and adiponectin). Endokrynologia, 18(2), 26-32. Retrieved from https://endokrynologia.com.ua/index.php/journal/article/view/387
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver

Download Citation

Endnote/Zotero/Mendeley (RIS) BibTeX

Abstract

The levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNFα), leptin and adiponectin (ADN) were investigated in the peripheral blood (PB) in 3 groups of patients (n=180): 1) with newly diagnosed type 2 diabetes mellitus (T2DM) (BMI=23.4±1.3 kg/m2), 2) with metabolic syndrome (MS) (BMI=33.5±2.0 kg/m2) and
T2DM+MS (BMI=31.1±0.7 kg/m2). 40 «lean» (BMI=22.8±0.5 kg/m2) and «obese» (BMI=31.1±0.7 kg/m2) healthy individuals served as controls. The increased levels of IL-6 and TNFα in PB with decreased ADN content without significant changes in leptin were noted in patients with T2DM without MS and obesity. A moderate increase in IL-6 and TNFα, marked decreased ADN and high level of leptin in the PB, were observed in patients with MS, especially in women. The highest content of IL-6 and TNFα was observed in patients with T2DM+MS under low level of ADN and simultaneous increased leptin content. The increased leptin concentration and decreased ADN level in the PB were also noted in healthy obese individuals without MS, comparing to lean individuals, but it was significantly lower than in patients with MS and MS+T2DM. Thus, increased levels of IL-6 and TNFα in T2DM have a dual character – independent and conditioned by the presence of metabolic syndrome/obesity. It is obvious, that summary of both mechanisms for entering these cytokines in the circulation is occurred in T2DM+MS. Increased leptin level in patients with T2DM is the result of simultaneous presence of excess body weight. Decreased ADN level indicates that it performs the antidiabetic protective role on the body in T2DM and MS.

pdf (Українська)

References

1. Зак К.П., Маньковский Б.Н., Мельниченко С.В. и др. Иммунитет у больных сахарным диабетом 2 типа с сопутствующим метаболическим синдромом/ожирением. Сообщение 1. Лейкоцитарный состав крови, иммунофенотип лимфоцитов и ультраструктура нейтрофилов // Эндокринология. 2013, 18,
№ 1, 27-36.
2. Carnethon M.R. Can we out-run the diabetes epidemic? // Diabetologia. 2007, 50, 1113-1115.
3. Nolan J.J., Fеrch K. Estimating insulin sensitivity and beta cell function: perspectives from the modern pandemics of obesity and type 2 diabetes // Diabetologia. 2012, 55, N 11, 2863-2867.
4. Eckel R.H., Kahn S.E., Ferrannini E. et al. Obesity and type 2 diabetes: What can be unified and what needs to be individualized // Diabetes Care. 2011, 34, N 6, 1424-1430.
5. Donath M.Y., Shoelson S.E. Type 2 diabetes as an inflammatory disease // Nat. Rev. Immunol. 2011, 11, N2, 98–107.
6. Gregor M.F., Hotamisligil G.S. Inflammatory mechanisms in obesity // Ann. Rev. Immunol. 2011, 29, 415-445.
7. Fernandez-Real J.-M., Pickup J.C. Innate immunity, insulin resistance and type 2 diabetes // Diabetologia. 2012, 55, N 2, 273-278.
8. Hotamisligil G.S. Inflammation and metabolic disorders // Nature. 2006, 444, N 7121, 860-867.
9. Ouchi N., Ohashi N., Shibata R., Murohara T. Adipocytokines and obesity-linked disorders // Nagoya J. Med. Sci. 2012, 74, N 1-2, 19-30.
10. Lumeng C.N., Saltiel A.R. Inflammatory links between obesity and metabolic disease // J. Clin. Invest. 2011, 121, N 6, 2111-2117.
11. Lawlor D.A., Smith G.D., Ebrahim S. Does the new International Diabetes Federation definition of the metabolic syndrome predict CHD any more strongly than older definitions? Findings from the British Women’s Heart and Health Study // Diabetologia. 2006, 49, N 1, 41-48.
12. Matthews D.R., Hosker I.P., Rudenski A.S. et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man // Diabetologia. 1985, 28, 412-419. Рисунок 4. Участие различных адипоцитокинов в механизме развития сахарного диабета 2 типа
13. Allen T.L., Febbraio M.A. IL-6 as a mediator of insulin resistance: fat or fiction? // Diabetologia. 2010, 53, N 3, 399-402.
14. Зак К.П., Кондрацкая И.Н., Попова В.В. Гормоны жировой ткани – адипоцитокины при сахарном диабете и его осложнениях (обзор литературы и собственные данные) // Врачебное дело. 2010, № 5-6, 39-55.
15. Wang X., Bao W., Liu J. et al. Inflammatory markers and risk of type 2 diabetes: A systematic review and meta-analysis // Diabetes Care. 2013, 36, N 1, 166-175.

Downloads

Download data is not yet available.