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Abstract
The purpose of the work was a comprehensive assessment of the effect of quercetin on the functional state of the central nervous and cardiovascular system in patients with ischemic stroke (II) and type 2 diabetes mellitus in the recovery period. Material and methods. In the clinic of the State Institution «D.F. Chebotarev Institute of Gerontology of NAMS of Ukraine» conducted an open pilot cohort prospective clinical study, which included 30 patients who had an atherothrombotic ischemic stroke in the carotid pool (19 women, 11 men) aged 55 to 75 years (average age 64.3±7.5 years), 30% had a history of type 2 diabetes. Before and after course administration of quercetin, patients underwent a comprehensive clinical, neurological and neuropsychological examination, a study of cerebral blood flow using ultrasound duplex scanning of extra- and intracranial sections of the main arteries of the head and neck, electrocardiography with an assessment of heart rate variability. All patients received quercetin (lyophilisate for the preparation of an injection solution (complex of quercetin with povidone), at the dose of 0.5 g per day for 10 days. To prepare a solution for intravenous administration, the drug was dissolved
in 100 ml of an isotonic solution NaCl and was administered intravenously drip for 15-20 minutes 1 time per day. Results. The article presents the results of a comprehensive assessment of the impact of the drug quercetin on functional condition of the central nervous and cardiovascular system in patients with diabetes mellitus and ischemic stroke in the recovery stroke period. In patients with left-hemispheric stroke quercetin has more pronounced effect on
the structure of the bioelectrical activity of the brain and cerebral hemodynamics than in patients with right-hemisphere localization of ischemic stroke. Patients undergoing ischemic stroke quercetin improves psycho-emotional and mnemonic function by positive reorganization of bioelectrical activity of the brain, improve cerebral hemodynamics and harmonization of the sympathetic and parasympathetic autonomic nervous system. Conclusion. Quercetin’s corrective influence on the functional state of the brain and the heart gives reason to recommend this drug in the system of rehabilitation of patients after ischemic stroke.
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