Effect of docetaxel and human beta-defensin-2 on proliferation of anaplastic thyroid carcinoma KTC-2 cells
Vol. 19 No. 1 (2014), ORIGINAL PAPERS
Vol. 19 No. 1 (2014)

Effect of docetaxel and human beta-defensin-2 on proliferation of anaplastic thyroid carcinoma KTC-2 cells

ORIGINAL PAPERS
Published March 20, 2014
O.L. Gerashchenko
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, Natl Acad. Sci. of Ukraine
O.V. Zhuravel
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, Natl Acad. Sci. of Ukraine
V.V. Pushkarev
State Institution «V.P. Komisarenko Institute of Endocrinology and Metabolism, Natl. Acad. Med. Sci. of Ukraine»
M.A. Soldatkina
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, Natl Acad. Sci. of Ukraine
V.M. Pushkarev
State Institution «V.P. Komisarenko Institute of Endocrinology and Metabolism, Natl. Acad. Med. Sci. of Ukraine»
P.V. Pogrebnoy
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, Natl Acad. Sci. of Ukraine
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Keywords

thyroid
anaplastic carcinoma
cell cycle
human beta-defensin-2
docetaxel

How to Cite

Gerashchenko, O., Zhuravel, O., Pushkarev, V., Soldatkina, M., Pushkarev, V., & Pogrebnoy, P. (2014). Effect of docetaxel and human beta-defensin-2 on proliferation of anaplastic thyroid carcinoma KTC-2 cells. Endokrynologia, 19(1), 11-15. Retrieved from https://endokrynologia.com.ua/index.php/journal/article/view/243
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Abstract

In present research we have studied the eff ect of docetaxel in ultralow concentrations (0.1-10 nM) and recombinant human beta-defensin-2 (hBD-2) in nanomolar  concentration range on proliferation and viability of anaplastic thyroid carcinoma cells of KTC-2 line, and expression of some cell cycle regulatory factors. It has been shown that docetaxel, hBD-2 and combination of these agents signif cantly inhibited proliferation of KTC-2 cells via down-regulation of the cyclin E expression.  

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Copyright (c) 2014 SI ≪V.P. Komisarenko Institute of Endocrinology and Metabolism, Natl. Acad. Med. Sci. of Ukraine≫

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