Correction of vaginal microflora in women with hyperandrogenia and reproductive losses at pregravid stage

Abstract

In modern conditions the role of endocrine pathology, including hyperandrogenia (HA) of various origin, was increased among the risk factors responsible for the  high rate of perinatal morbidity and mortality. Infectious factor should be accented among the principal etiologic factors of fetal loss syndrome. Studying the state of  the cervical canal in women with hyperandrogenia, including the high frequency (up to 34%) of functional isthmic-cervical insufciency in these contingent of patients,  appears to be essential. The secretion of cervical mucus is a barrier to ascending infection. The protective effects of mucous coating, and especially the local complex of  antimicrobial protection that makes to investigate the status of vaginal microbiocenosis as a potential reservoir of pathogens that can cause a pathological process and  promptly correct it at pregravid stage, are the main factors involved in the phenomenon of colonization resistance of the mucous membranes by the body.