Effect of prolonged antihypertensive treatment on the structure of relationships between indicators of endothelial dysfunction and platelet hemostasis in patients with compensated type 2 diabetes mellitus

Abstract

The aim of this study is to determine the effect of antihypertensive therapy on the structure of relationships between endothelial dysfunction, degree of kidney  function damage, lipidemic profile, and morphological changes in vascular-platelet hemostasis in patients with a well-controlled type 2 diabetes mellitus and arterial  hypertension. In 69 patients, using clinical, laboratory, morphological methods and correlation analysis, the relationships were identified between endothelial dysfunction, degree of renal function damage, lipidemic profile, and morphological changes in vascular-platelet hemostasis during one year of antihypertensive therapy. In the presence of a good control of hyperglycemia, morphological criteria of platelet hemostasis damage strongly correlated with the  markers of endothelial dysfunction, but did not show any significant relationships with most indicators of renal function and blood lipid profile. Thus, the use of  blockers of angiotensin II receptor antagonists does not substantially change the structure of relationships between the indicators of endothelial dysfunction,  nephropathic and dyslipidemic disorders, damage of platelet hemostasis compared with standard antihypertensive therapy.