Testosterone replacement in therapy of men with type 2 diabetes and testosterone deficiency syndrome

Abstract

Aim is to study an effect of replacement therapy with testosterone of prolonged action on the functional state of the pituitary-gonadal system, clinical symptoms of  androgen deficiency in patients with type 2 diabetes mellitus (T2DM) with androgen deficiency. Material and Methods. 35 male with T2DM, aged 39- 72 years, the  duration of diabetes — 2-14 years, with symptoms of testosterone deficiency, and blood total testosterone (T) levels <10.4 nmol/l were involved in the study. 100 mg of  testosterone oil solution, undecanoate, were used for replacement treatment. There was a significant increase in total blood testosterone concentration in 3 and 6  months after an initiation of treatment by 14.6±0.9 nmol/l and 17.0±0.7 nmol/l, respectively vs 8.3±0.5 nmol/l before treatment (p<0.05). Changes in the average levels  of lutropin and estradiol were not observed during treatment. No clinically significant side effects were observed. Conclusions. Long-acting testosterone undecanoate  administration resulted in the normalization of the total testosterone level and improvement of the erectile function in  men with type 2 diabetes and androgen  deficiency.