Significance of marker Growth differentiation factor 15, as a risk factor in patients with type 2 diabetes with acute coronary syndrome

Abstract

Type 2 diabetes mellitus (DM2) is frequently observed in patients with acute coronary syndrome (ACS). The relationship between the level of Growth differentiation  factor 15 (GDF-15) and DM2 is discussed in recent studies. Aim: to study the relationship  between GDF-15 and DM2 in patients with ACS. Materials and methods: 73  patients with different forms of ACS were examined. The levels of biomarkers — GDF-15 and N-terminal pro brain natriuretic peptide (NT-pro BNP) were determined.  Follow-up period consisted of 1 year. End point is defined as fatal outcome. Results. Taking into account the significant differences identified level of GDF-15, an  attempt to evaluate the prognostic value of GDF-15 was made in patients with type 2 diabetes using the ROC-analysis. The levels of GDF-15 3894 pg/ml, 64% sensitivity  and 75% specificity were determined as threshold ones. Conclusions. Patients with ACS and DM2 more often have different cardiovascular diseases and such risk  factors as decreased level of HDL, and increased level of C-reactive protein comparing to patients without diabetes. GDF-15 level was significantly higher in patients  with ACS and DM2.