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Abstract. Aim is to evaluate the effect of blueberry paste on metabolic profile of middle-aged patents with metabolic syndrome and type 2 diabetes. Materials and methods. 35 patients with metabolic syndrome (MS) and type 2 diabetes (25 women and 10 men) aged 45-59 ears were included into the study. The main group of 17 patients received blueberry paste (Liqberry, Ukraine) at a dose of 0.5 g/kg/body weight per day for three months additionally to pharmacotherapy for type 2 diabetes. Control group (18 patients) received only pharmacotherapy for type 2 diabetes. Anthropometric characteristics, indices of body composition, lipid and glucose profiles were measured. Results. A significant weight lost from 90.5 (85.0;104.0) kg to 87.9 (85.4;101.8) kg (p=0.03), and a decrease in BMI, p=0.03, respectively was revealed in patients against the background of paste application. Additionally, a significant decrease in hip circumference from 111 (105;118) cm to 108 (102;118) cm, p=0.07 was noted. A positive effect on lipid metabolism was expressed by increased HDL cholesterol levels (p=0.04). The decrease in insulin level from 9.8 (6.3;11.6) to 6.0 (5.0;10.2) μkU/ml (p=0.03) and in HOMA-IR from 3.2 (2.1;4.0) to 2.3 (1.7;3.4) (p=0.04) demonstrate an improvement of insulin sensitivity in patients taking bilberry paste. On the contrary, the body weight and BMI were increased (p=0.01) at the end of the study period and visceral fat level was also increased (p=0.04) in the control group. Moreover, HOMA-IR increased from 2.1 (1.7;2.4) to 3.3 (1.5;4.5), p=0.03, due to insulin level rise in control group. Conclusions. Indices of metabolic profile in patients with metabolic syndrome and type II diabetes, including reduction of body weight and insulin resistance, were improved by additional bilberry paste supplementation.
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