The combined herbal remedy Sedariston effect on carbohydrate metabolism and the psychomotional state of diabeti c patients with depressive syndrome

Abstract

The aim was to study the effect of the combined herbal product Sedariston, containing  standardized dry extracts of Hypericum (100 mg) and Valerian (50 mg) (esparma GmbH, Germany), on carbohydrate metabolism and psycho-emotional state of diabetic patients with depressive syndrome. Material and methods. The study included 60 patients with type I and type II diabetes with a depressive syndrome diagnosed according to the Beck and PHQ‑9 scales. All patients consistently took standard insulin therapy and/or hypoglycemic oral medications. 30 patients from the total number of patients additionally took Sedariston 2 capsules twice a day for 2 months. Before starting the application of Sedariston, and over the next 3 months, the psycho-emotional state was assessed by the Beck and PHQ‑9 scales: after 2 weeks, 1, 2 and 3 months. The state of carbohydrate metabolism (according to glycated hemoglobin and glycemia) was assessed in 3 months after the start of monitoring. Results. Patients, who took Sedariston, showed a significant improvement in the symptoms of depressive syndrome with significant decrease according to the PHQ‑9 score from 13.1±1.4 to 8.6±1.4 (p<0.05) in a month after treatment, and according to Beck’s scale from 23.2±1.5 to 17.7±2.0 (p<0.05) in 2 months after treatment with a subsequent improvement, in contrast to patients who did not take Sedariston: 11.4±1.0 vs 9.9±1.0 (p>0,1) by the PHQ‑9 scale and 17.6±1.1 vs 17.1±2.1 (p>0,1) by the Beck scale, respectively. 3 months after the start of Sedariston application, against the background of the positive dynamics of depressive syndrome in patients, there was a decrease in glycated hemoglobin from 9.8±0.5% to 7.9±0.3% (p<0.01) in contrast to patients, who did not apply Sedariston: 8.8±0.2% vs 9.0±0.4% (p>0.1), respectively. In addition, in 3 months after therapy, the average daily glycemia level in patients applying Sedariston decreased from 13.1±0.8 mmol/l to 10.0±0.5 mmol/l (p<0.01), comparing with patients, who have not applied it: 11,4±0,6 mmol/l vs 11.8±1.0 mmol/l (p>0.1), respectively. Conclusions. Sedariston application (2 capsules 2 times a day) for 2 months in the complex therapy of patients with diabetes, besides having a positive long-term effect on the symptoms of the depressive syndrome, had a positive effect on carbohydrate metabolism, with a 3-month decrease in glycated hemoglobin by 1.9%. This indicates the need for a timely diagnosis of depression in patients with diabetes and the expediency of therapy with the combined herbal product Sedariston for improving the psycho-emotional state, and also for normalizing carbohydrate metabolism disorders.