The сytological features of thyrocytes of reccurent thyroid papillary carcinomas with repeated metastasis

Abstract

Aim. Is cytomorphological and imunocytochemical studies of thyrocytes of punctates of metastases reccurent papillary carcinomas with repeated metastasis and comparative analysis of cytological characteristics of therocytes of primary and repeated postoperative metastases of each patient. Material and methods. Cytomorphological and imunocytochemical studies using monoclonal antibodies against thyroid peroxidase, thyroglobulin and antigen Ki‑67 were perfomed on the material of Fine Needle Aspiration Biopsy of 26 metastases of 12 reccurent papillary carcinomas with repeated metastasis. Results. It was shown a statistically significant reduction in the expression of thyroid peroxidase and thyroglobulin and the appearance of phenotypic heterogeneity in the thyroid population (light cells, macular cells, and oxyphilic cells) of repeated metastases compared to primary ones. The change in the phenotypic characteristics of metastases reflected the loss of cell differentiation from primary to secondary metastases and loss of radioiodine sensitivity. Conclusion. As a result of cytomorphological and immunocytochemical studies of punctures of recurrent papillary carcinoma metastases with repeated metastases, it has been shown that the phenotypic characteristics of the recurrent metastasis of these thyroid carcinomas show a tendency to loss of differentiation their cells (statistically significant decrease in the expression of thyroid peroxidase and thyroglobulin, and the appearance of phenotypic heterogeneity of thyrocytes’ population).