Thyroid status in patients with obesity of different degree

Abstract

Purpose. To assess the state of the thyroid balance in middle-aged men with obesity of different degree depending on the presence of the metabolic syndrome (MS). Materials and
methods. A total of 58 middle-aged men (45-59 years old), whose body weight was above normal were examined. The examination program included determination of the following indices: serum insulin level along with the calculation of the HOMA-IR index, cortisol, thyroid-stimulating hormone (TSH), total thyroxin (tT4), free thyroxin (fT4), total triiodothyronine (tT3), free triiodothyronine (fT3) thyroglobulin antibodies (TG Ab), thyroid peroxidase antibodies (TPO Ab), total cholesterol (TC), HDL and LDL cholesterol, triglycerides (TG), and glucose. The level of microalbuminuria (MAU) was determined in urine. The ultrasonography of the kidneys, liver, gall bladder, thyroid gland, and intra-abdominal adipose tissue was performed. Results. Patients were divided into two groups, depending on the presence of MS and the values of BMI: Group 1 — BMI over 30 kg/m2 with signs of MS; Group 2 — BMI
of 25-30 kg/m2 with no signs of MS. The following indices were significantly elevated in blood of patients in Group 1: serum levels of cortisol, TSH, tT4, fT4/fT3 ratio, TPO Ab, cholesterol, triglycerides, LDL cholesterol. Conclusion. Dysthyroidism, hyperthyrotropinemia, hypercortisolemia, dyslipidemia are observed in men with obesity and MS.