Role of mitogen-activated protein kinase (MAPK) in processes of proliferation in human thyroid tumors
Vol. 21 No. 1 (2016), ORIGINAL PAPERS
Vol. 21 No. 1 (2016)

Role of mitogen-activated protein kinase (MAPK) in processes of proliferation in human thyroid tumors

ORIGINAL PAPERS
Published March 31, 2016
B.B. Guda
State Institution «V.P. Komisarenko Institute of Endocrinology and Metabolism of National Academy of Medical Scienced of Ukraine»
V.M. Pushkarev
State Institution «V.P. Komisarenko Institute of Endocrinology and Metabolism of National Academy of Medical Scienced of Ukraine»
V.V. Pushkarev
State Institution «V.P. Komisarenko Institute of Endocrinology and Metabolism of National Academy of Medical Scienced of Ukraine»
A.Ye. Kovalenko
State Institution «V.P. Komisarenko Institute of Endocrinology and Metabolism of National Academy of Medical Scienced of Ukraine»
Y.M. Taraschenko
State Institution «V.P. Komisarenko Institute of Endocrinology and Metabolism of National Academy of Medical Scienced of Ukraine»
O.V. Zhuravel
State Institution «V.P. Komisarenko Institute of Endocrinology and Metabolism of National Academy of Medical Scienced of Ukraine»
P.P. Zinych
State Institution «V.P. Komisarenko Institute of Endocrinology and Metabolism of National Academy of Medical Scienced of Ukraine»
L.Y. Zurnadzhy
State Institution «V.P. Komisarenko Institute of Endocrinology and Metabolism of National Academy of Medical Scienced of Ukraine»
O.I. Kovzun
State Institution «V.P. Komisarenko Institute of Endocrinology and Metabolism of National Academy of Medical Scienced of Ukraine»
M.D. Tronko
State Institution «V.P. Komisarenko Institute of Endocrinology and Metabolism of National Academy of Medical Scienced of Ukraine»
Pdf (Українська)

Keywords

thyroid tumors, extracellular signal — regulated kinase‑1/2, proliferating cell nuclear antigen

How to Cite

Guda, B., Pushkarev, V., Pushkarev, V., Kovalenko, A., Taraschenko, Y., Zhuravel, O., Zinych, P., Zurnadzhy, L., Kovzun, O., & Tronko, M. (2016). Role of mitogen-activated protein kinase (MAPK) in processes of proliferation in human thyroid tumors. Endokrynologia, 21(1), 5-9. Retrieved from https://endokrynologia.com.ua/index.php/journal/article/view/109
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Abstract

Effector kinase of the MAPK (mitogen-activated protein kinase)-pathway — extracellular signal-regulated kinase‑1/2 (ERK1/2) activation and expression and proliferating cell nuclear antigen (PCNA) content in normal tissues, benign and well-differentiated malignant (metastatic and not metastatic) human thyroid tumors were studied. In malignant tumors and tissue of follicular adenoma’s increased PCNA expression was observed, and the amount of antigen in tumor tissue, except for follicular carcinoma, exceeded the amount in the conditionally normal tissue. Importantly, in encapsulated papillary carcinomas this excess was 85%, while in non-encapsulated, metastatic tumors PCNA content was on average more than 3 times above normal, and in the cases of most aggressive tumors with metastases in lungs — even 4 times. PCNA amount in thyroid tissue could serve as one of diagnostic and prognostic markers, and development of effective antigen inhibitors may be a promising trend in thyroid cancer treatment. Total ERK content was significantly lower in tumors compared to normal tissue, except goiter. Phosphorylation (activation) of the ERK was almost completely suppressed in tumors but not in normal tissue. Evidently, ERK activation is not associated with proliferative processes in thyroid tumor tissue. The possible mechanisms of MAPK cascade inhibition in thyroid tumors are discussed.

Pdf (Українська)

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