Application of metabolic therapy in pathogenetic treatment of patientes with diabetic foot syndrome
ARTICLE PDF

Keywords

diabetes mellitus, diabetic foot syndrome, neurovascular mechanisms, metabolic therapy, alpha-lipoic acid, aldose reductase inhibitors

How to Cite

Garnitskaya, A. (2018). Application of metabolic therapy in pathogenetic treatment of patientes with diabetic foot syndrome. Endokrynologia, 23(4), 356-361. https://doi.org/10.31793/1680-1466.2018.23-4.356

Abstract

According to modern recommendations concerning the treatment of diabetic foot syndrome, it is necessary along with intensive control of carbohydrate and lipid metabolism, to use the strategy of early application of agents that promote pathogenetic correction of diabetic polyneuropathy and angiopathy, the main links in the development of lesions of lower extremity tissues. Means of metabolic therapy can counteract the influence of such pathogenetic factors as chronic hyperglycemia, activation of the polyol pathway, oxidative stress, glycation of structural, transport and receptor proteins, disruption of nerve growth and regeneration. Timely administration of alpha-lipoic acid, aldose reductase inhibitors, B-group vitamins, antithrombotics, prevention of glycation and stimulation of nerve growth factors can slow or prevent the passage of SDS into a purulent-necrotic form, reducing the risk of trophic ulceration and amputation.

https://doi.org/10.31793/1680-1466.2018.23-4.356
ARTICLE PDF
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.