Biochemical mechanisms connecting diabetes and cancer. Effects of methormine

Abstract

A review of the literature summarizes and analyzes material on biochemical mechanisms that link the pathogenesis of cancer and diabetes. Data on the involvement of hyperinsulinemia, hyperglycemia, caused by obesity chronic inflammation, autophagy defects and endoplasmic reticulum stress in the pathological transformation of cells of various tissues and organs are presented. Particular attention is paid to the antitumor activity of metformin, the most important hypoglycemic drug used in type 2 diabetes. The relationship between diabetes and various types of cancer is described. The prospects of using antidiabetic drugs for the prevention and treatment of cancer are evaluated.