Keywords
cortisol
insulin
adaptive-compensatory capabilities
oligomenorrhea
voltage coefficient – С/In ratio
How to Cite
Abstract
Abstract. Menstrual dysfunction remains a pressing problem of modern medicine. Along with many adverse factors affecting the health of girls who should be considered as future mothers, the impact of traumatic events occupies one of the leading places. Stress is a complex adaptive reaction that requires additional energy expenditure. Under its influence, the functioning of both the hypothalamic-pituitary-adrenal axis (HPAA) and insulin (In) secretion changes.
The aim of the study was to determine the characteristics of the stress response in girls with oligomenorrhea (OM) in a frontline city.
Material and methods. To assess the adaptive capabilities, the serum levels of cortisol (C) and In and their ratio were studied in 116 girls with OM. All patients were divided into groups depending on the duration of OM. The 1-st group included 20 girls who sought medical help in the first year after menarche. The 2-nd group included 28 adolescents with the disease for up to 2 years, the 3-rd group consisted of 39 patients with OM for up to 3 years, and the 4-th group included 39 patients with OM for more than 3 years.
Results. The function of the adrenal glands and the pancreas in terms of C and In synthesis was preserved in half of the girls with OM, as evidenced by the C/In ratio, which fluctuated within the normal range. A decrease in this index was noted in more than thirds, and from 3 to 10% of girls had an increase in the stress index. It was established that when OM occurs in the first year of menstruation, high numbers of the stress index (C/In) are not noted, which indicate a decrease in the reserves of the body's compensatory capabilities and a disruption in the energy supply of adaptive processes. With the extension of the OM duration, signs of exhaustion already appear, that is an inadequate response of the body to the chronicity of the process.
Conclusions. As a result of the conducted research and analysis of the identified violations, it was found that 39.7% of patients with OM have adaptation disorders. These deviations emphasize the need to identify adaptive resources to address the issue of their correction in order to increase the body's ability to tolerate stress and strengthen adaptive capabilities.
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