Abstract
Suggest a strong relationship between vitamin D (vit. D) and the growth hormone (GH)/insulin-like growth factor-1 axis and the possible influence of vit. D on child growth, but the exact mechanism of their interaction has not yet been clarified. The aim of our study was to investigate the vitamin D status in children with GH deficiency. Material and methods. We examined 36 children with GH deficiency treated in the State Institution «V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine». Statistical processing of the study results was performed using Microsoft Excel statistical programs. Results. The majority of patients (31 children; 86.11%) had hypovitaminosis D (deficiency – 17 patients, insufficiency – 14 patients). Vit. D deficiency was detected in 50% of male children with GH deficiency, insufficiency –in 35.7% of boys, and only 14.3% had normal vit. D level. At the same time, vit. D insufficiency was mainly observed among girls (50% of cases), and vit. D deficiency was found in 37.5% of female children with GH deficiency, and a normal vit. D level – in 12.5%. The basal GH level in children with vit. D deficiency was low, but it was 3.6 times lower in girls than in boys; in children with vit. D insufficiency, the basal GH level was 2.5 times lower in boys than in girls. During the insulin test, an increase in the GH level was observed
regardless of the vit. D level, but did not reach normal values, indicating its absolute insufficiency. GH level after insulin stimulation was 2.1 times higher in boys with vit. D deficiency than in girls, and 1.6 times higher in girls with vit. D insufficiency compared to the opposite sex. The level of insulin-like growth factor-1 was 0.7 times lower in boys with vit. D deficiency and 0.7 times lower in girls with vitamin D insufficiency compared to boys. All biochemical parameters studied were within normal limits, regardless of the patient’s gender. Conclusions. In most patients (86.11%) with GH deficiency, hypovitaminosis D is observed against the background of a sharp decrease in basal and stimulated GH levels (deficiency – in 47.22% of patients, insufficiency – in 38.88% of patients). Vit. D deficiency was observed more often in boys, vit. D insufficiency – in girls. The presence of hypovitaminosis D in children with GH deficiency determines the advisability of including vit. D preparations into complex therapy of such patients.
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