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Abstract
Chronic stress is a risk factor for the development of lipid and carbohydrate metabolism disorders, obesity and type 2 diabetes (T2D). The purpose of the work was to assess the state of carbohydrate and lipid metabolism and the rate of metabolic aging in civilian women of various ages during the war. Material and methods. We examined 91 women of all ages who, during active hostilities in February and March 2022, were influenced by such war factors as rocket and artillery attacks, staying in bomb shelters or other shelters. The data of 79 women of different ages examined before the Russian-Ukrainian war were used for comparison. Anthropometric parameters, fasting plasma blood glucose concentration and after 2 hours of the standard glucose tolerance test (GTT), plasma insulin and cortisol levels were determined, and the HOMA-IR insulin resistance index was calculated. Results. Women examined during the war had a statistically significantly higher concentration of glucose in the blood both fasting and after 2 h of the standard GTT, insulin and a higher index of insulin resistance NOMA-IR compared to the group of women examined before the war. The FINDRISK total score indicates an increased risk of developing T2D in the next 10 years. Women of all three age groups examined during the war had a statistically significantly higher plasma blood cortisol concentration than in the corresponding groups of women examined before the war. An increase in the frequency of prediabetic disorders of carbohydrate metabolism was revealed in comparison with their frequency before the war. An acceleration in the rate of metabolic aging during the war occurred in young women (up to 45 years old) and older women (60-74 years old). Conclusion. Post-traumatic stress associated with the war led to disturbance of carbohydrate and lipid metabolism. More significant changes were observed in older women. During the war, the frequency of prediabetic carbohydrate metabolism disorders in women increases, the risk of developing T2D in the next 10 years increases, and the rate of metabolic aging accelerates.
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