Keywords
adrenal cortex, signal transduction, biochemical mechanisms, signaling pathways
How to Cite
Lukashenia, O. (2017). Modern views on signal transduction systems in adrenocorticocytes (literature review and own research). Endokrynologia, 22(2), 146-159. Retrieved from https://endokrynologia.com.ua/index.php/journal/article/view/72
Abstract
The biochemical processes associated with signal transduction in adrenal cortex cells are described in the review. The role of new types of protein kinases and transcription nuclear factors in the regulation of fundamental biological processes has been established. Intracellular signaling systems links can be considered as the possible pathogenesis links of several diseases as well as their therapy targets.
References
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10. Szarek E., Stratakis C.A. Phosphodiesterases and adrenal Cushing in mice and humans // Horm. Metab. Res. — 2014. — Vol. 46, № 12. — Р. 863-868.
11. Shimizu-Albergine M., Tsai L.C., Patrucco E., Beavo J.A. cAMPspecific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis // Mol. Pharmacol. — 2012. — Vol. 81, № 4. — Р. 556-566.
12. LaVoie H.A., King S.R. Transcriptional regulation of steroidogenic genes: STARD1, CYP11A1 and HSD3B // Exp. Biol. Med. — 2009. — Vol. 234. — P. 880-907.
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2. Gallo-Payet N. 60 years of POMC: adrenal and extra-adrenal functions of ACTH // J. Mol. Endocrinol. — 2016. — Vol. 56, № 4. — Р. T135-Т156.
3. Cone R.D., Mountjoy K.G., Robbins L.S., Nadeau J.H., Johnson K.R., Roselli-Rehfuss L., Mortrud M.T. Cloning and functional characterization of a family of receptors for the melanotropic
peptides // Ann. N.Y. Acad. Sci. — 1993. — Vol. 680. — P. 342-363.
4. Gallo-Payet N., Cote M., Chorvatova A., Guillon G., Payet M.D. Cyclic AMP-independent effects of ACTH on glomerulosa cells of the rat adrenal cortex // J. Steroid Biochem. Mol. Biol. — 1999. — Vol. 69. — P. 335-342.
5. Whitehouse B.J., Abayasekara D.R.E. Roles of type I and type II isoenzymes of cyclic AMP-dependent protein kinase in steroidogenesis in rat adrenal cells // J. Mol. Endocrinol. — 1994. — Vol. 12. — P. 195-202.
6. Yu B., Ragazzon B., Rizk-Rabin M., Bertherat J. Protein kinase A alterations in endocrine tumors // Horm. Metab. Res. — 2012. — Vol. 44, № 10. — Р. 741-748.
7. Mantovani G., Lania A.G., Bondioni S., Peverelli E., Pedroni C., Ferrero S., Pellegrini C., Vicentini L., Arnaldi G., Bosari S., Beck-Peccoz P., Spada A. Different expression of protein kinase A (PKA) regulatory subunits in cortisol-secreting adrenocortical tumors: relationship with cell proliferation // Exp. Cell Res. — 2008. — Vol. 314, № 1. — Р. 123-130.
8. Cote M., Guillon G., Payet M.D., Gallo-Payet N. Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland // J. Clin. Endocrinol. Metab. — 2001. — Vol. 86, № 9. — P. 4495-4503.
9. Shen T., Suzuki Y., Poyard M., Best-Belpomme M., Defer N., Hanoune J. Localization and differential expression of adenylyl cyclase messenger ribonucleic acids in rat adrenal gland determined by in situ hybridization // Endocrinology. — 1997. — Vol. 138. — P. 4591-4598.
10. Szarek E., Stratakis C.A. Phosphodiesterases and adrenal Cushing in mice and humans // Horm. Metab. Res. — 2014. — Vol. 46, № 12. — Р. 863-868.
11. Shimizu-Albergine M., Tsai L.C., Patrucco E., Beavo J.A. cAMPspecific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis // Mol. Pharmacol. — 2012. — Vol. 81, № 4. — Р. 556-566.
12. LaVoie H.A., King S.R. Transcriptional regulation of steroidogenic genes: STARD1, CYP11A1 and HSD3B // Exp. Biol. Med. — 2009. — Vol. 234. — P. 880-907.
13. Ruggiero C., Lalli E. Impact of ACTH signaling on transcriptional regulation of steroidogenic genes // Front Endocrinol. — 2016. — Vol. 7. — Р. 24.
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